Johanna Lou1, Ambria S Moten2, Sanjay S Reddy3, Krisha J Howell4, Sujana Movva5, Margaret von Mehren5, Jeffrey M Farma6. 1. Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania. 2. Department of Surgery, Temple University Hospital, Philadelphia, Pennsylvania. 3. Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania. 4. Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania. 5. Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania. 6. Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Electronic address: Jeffrey.Farma@fccc.edu.
Abstract
BACKGROUND: Sarcomas are malignant tumors of connective tissue that can vary widely in etiology. Parameters such as grade, extent of resection, and tumor integrity have been shown to affect prognosis. Our principal aim was to examine associations between the laterality of retroperitoneal sarcomas and tumor characteristics, treatment, and patient outcomes. MATERIALS AND METHODS: We performed a retrospective study of patients treated at our tertiary referral center with a diagnosis of primary retroperitoneal sarcoma who underwent tumor resection. Categorical variables were compared using the chi-square test, whereas continuous variables were compared using one-way analysis of variance. Cox regression was used to estimate the risk of death. RESULTS: Data from 106 patients were analyzed. A greater proportion of bilateral or midline tumors were leiomyosarcomas (P = 0.02), whereas right-sided tumors were more likely to be liposarcoma (P = 0.02). There was no significant relationship between laterality and tumor grade or stage. Two-thirds of patients had at least one contiguous organ resected (n = 68, 65.4%). Patients with nephrectomy during sarcoma resection were more likely to have right-sided disease (P = 0.02). Splenectomy and pancreatectomy were associated with left-sided disease (P < 0.01; P < 0.01), and pancreaticoduodenectomies with bilateral or midline disease (P < 0.001). Adjusting for age, sex, race, grade, stage, histology, and treatment, there was no increased risk of death or recurrence based on laterality. CONCLUSIONS: Although laterality did not seem to have a measurable relationship with patient outcomes or survival, there was a significant association between laterality, tumor histology, and resection of contiguous organs. These preliminary findings warrant further investigation.
BACKGROUND:Sarcomas are malignant tumors of connective tissue that can vary widely in etiology. Parameters such as grade, extent of resection, and tumor integrity have been shown to affect prognosis. Our principal aim was to examine associations between the laterality of retroperitoneal sarcomas and tumor characteristics, treatment, and patient outcomes. MATERIALS AND METHODS: We performed a retrospective study of patients treated at our tertiary referral center with a diagnosis of primary retroperitoneal sarcoma who underwent tumor resection. Categorical variables were compared using the chi-square test, whereas continuous variables were compared using one-way analysis of variance. Cox regression was used to estimate the risk of death. RESULTS: Data from 106 patients were analyzed. A greater proportion of bilateral or midline tumors were leiomyosarcomas (P = 0.02), whereas right-sided tumors were more likely to be liposarcoma (P = 0.02). There was no significant relationship between laterality and tumor grade or stage. Two-thirds of patients had at least one contiguous organ resected (n = 68, 65.4%). Patients with nephrectomy during sarcoma resection were more likely to have right-sided disease (P = 0.02). Splenectomy and pancreatectomy were associated with left-sided disease (P < 0.01; P < 0.01), and pancreaticoduodenectomies with bilateral or midline disease (P < 0.001). Adjusting for age, sex, race, grade, stage, histology, and treatment, there was no increased risk of death or recurrence based on laterality. CONCLUSIONS: Although laterality did not seem to have a measurable relationship with patient outcomes or survival, there was a significant association between laterality, tumor histology, and resection of contiguous organs. These preliminary findings warrant further investigation.
Authors: A Gronchi; R Miceli; C Colombo; S Stacchiotti; P Collini; L Mariani; C Sangalli; S Radaelli; R Sanfilippo; M Fiore; P G Casali Journal: Ann Oncol Date: 2011-07-16 Impact factor: 32.976
Authors: Alessandro Gronchi; Dirk C Strauss; Rosalba Miceli; Sylvie Bonvalot; Carol J Swallow; Peter Hohenberger; Frits Van Coevorden; Piotr Rutkowski; Dario Callegaro; Andrew J Hayes; Charles Honoré; Mark Fairweather; Amanda Cannell; Jens Jakob; Rick L Haas; Milena Szacht; Marco Fiore; Paolo G Casali; Raphael E Pollock; Chandrajit P Raut Journal: Ann Surg Date: 2016-05 Impact factor: 12.969
Authors: Emily Z Keung; Jason L Hornick; Monica M Bertagnolli; Elizabeth H Baldini; Chandrajit P Raut Journal: J Am Coll Surg Date: 2013-10-25 Impact factor: 6.113
Authors: J T Miura; J Charlson; T C Gamblin; D Eastwood; A Banerjee; F M Johnston; K K Turaga Journal: Eur J Surg Oncol Date: 2015-07-29 Impact factor: 4.424
Authors: Imran Hassan; Saung Z Park; John H Donohue; David M Nagorney; Paul A Kay; Antonio G Nasciemento; Cathy D Schleck; Duane M Ilstrup Journal: Ann Surg Date: 2004-02 Impact factor: 12.969