Hypolipidemic effect of polysaccharides from Fortunella margarita (Lour.) Swingle in hyperlipidemic rats.

The objective was to investigate the hypolipidemic effect of polysaccharides from Fortunellamargarita (Lour.) Swingle (FMPS) in hyperlipidemic rats and the comparative relationship between in vitro and in vivo. After FMPS feeding, the body weight, liver and spleen index of the hyperlipidemic rats decreased significantly, in a dose-dependent manner. The content of triglyceride, total cholesterol, low density lipoprotein and serum non-esterified fatty acid decreased, and high density lipoprotein, and serum lipase significantly increased after FMPS feeding in hyperlipidemic rats. Notably, high-dose FMPS, exhibited effective hypolipidemic activity, as compared with that of simvastatin. Moreover, histopathological micrographs of hepatic tissue and blood vessel morphology indicated that the fat deposition in liver cells decreased, and the vascular endothelial cells were protected by FMPS. Furthermore, the activities of superoxide dismutase, total antioxidant capacity, glutathione peroxidase, and glutathione-S-transferase were enhanced, and the content of malondialdehyde was decreased by FMPS feeding in the hyperlipidemic rats. A concentration-dependent response was observed. Similarly to the hypolipidemic effect observed in vitro, the hypolipidemic effect of FMPS in hyperlipidemic rats was achieved by decreasing the lipid content and enhancing the activity of antioxidant enzymes. Thus, FMPS had a major role in regulating the lipid metabolism disorder in hyperlipidemic rats.