| Literature DB >> 31278965 |
Dongyu Chuo1, Fang Liu1, Yuze Chen1, Mingdi Yin2.
Abstract
In this study we investigated the role of lncRNA MIR503HG in colorectal cancer (CRC). We found that MIR503HG was downregulated and TGF-β2 was upregulated in CRC included in this study. Low levels of MIR503HG were associated with poor survival of CRC patients within 5 years after admission. MIR503HG and TGF-β2 were inversely correlated in CRC tissues, and in CRC cells, MIR503HG overexpression was accompanied by TGF-β2 downregulation, while TGF-β2 overexpression did not affect MIR503HG. TGF-β2 overexpression mediated the increased migration and invasion rates of CRC cells. MIR503HG overexpression mediated the decreased migration and invasion rates of CRC cells. Moreover, TGF-β2 overexpression reduced the effects of MIR503HG overexpression. Therefore, MIR503HG overexpression inhibits CRC cell migration and invasion mediated by TGF-β2.Entities:
Keywords: Colorectal cancer; Survival; TGF-β2; lncRNA MIR503HG
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Year: 2019 PMID： 31278965 DOI： 10.1016/j.gene.2019.143960
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688