Literature DB >> 3127853

Morphine induces delayed anorexia in rats.

M Leshem1.   

Abstract

The delayed suppression of feeding caused by morphine was investigated in the rat. A single injection of morphine evoked a triphasic influence on feeding: a brief (1 h) severe anorexia was followed by hyperphagia (3 h) and a mild (20%) yet persistent (4-24 h) anorexia. This latter anorexic effect was at least partially naltrexone reversible, and the duration of this antagonism (8 h) was longer than that of naltrexone's anorexic effect (4 h). Delayed morphine anorexia cannot be ascribed to morphine's initial stuporific influence, and it was not dependent upon previous feeding or deprivation. It was not due to gastric distension. The specificity and significance of this anorexia is discussed.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3127853     DOI： 10.1007/bf00176855

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  25 in total

1.  Treatment of chronic anorexia nervosa with opiate blockade.

Authors:  E D Luby; M A Marrazzi; J Kinzie
Journal:  J Clin Psychopharmacol       Date:  1987-02       Impact factor: 3.153

2.  Low doses of naloxone and MIF-1 peptides increase fluid consumption in rats.

Authors:  R D Olson; R C Fernandez; A J Kastin; G A Olson; S W Delatte; T K von Almen; D G Erickson; D C Hastings; D H Coy
Journal:  Pharmacol Biochem Behav       Date:  1981-12       Impact factor: 3.533

3.  Chronic naltrexone administration reverses the suppressive effect of crowding on body weight gain in rats.

Authors:  S Amir; H Z Galina; Z Amit
Journal:  Neuropharmacology       Date:  1979-11       Impact factor: 5.250

Review 4.  Endorphinergic mechanisms in food, salt and water intake: an overview.

Authors:  S J Cooper; D J Sanger
Journal:  Appetite       Date:  1984-03       Impact factor: 3.868

5.  A convenient feeder for measurement of consumption of powdered food by rats.

Authors:  M Leshem
Journal:  Physiol Behav       Date:  1981-08

6.  Behaviourally-specific hyperdipsia in the non-deprived rat following acute morphine treatment.

Authors:  S J Cooper
Journal:  Neuropharmacology       Date:  1981-05       Impact factor: 5.250

7.  Suppression of feeding by naloxone in rat: a dose-response comparison of anorexia and conditioned taste aversion suggesting a specific anorexic effect.

Authors:  M Leshem
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

8.  Opposite effects of morphine on feeding and drinking in rats relative to administration time.

Authors:  M Kunihara; M Kanbayashi; T Ohshima
Journal:  Jpn J Pharmacol       Date:  1983-08

9.  beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa).

Authors:  D L Margules; B Moisset; M J Lewis; H Shibuya; C B Pert
Journal:  Science       Date:  1978-12-01       Impact factor: 47.728

10.  Morphine selectively influences macronutrient intake in the rat.

Authors:  R Marks-Kaufman; R B Kanarek
Journal:  Pharmacol Biochem Behav       Date:  1980-03       Impact factor: 3.533
View more
  5 in total

1.  Rats self-administer sufentanil in aerosol form.

Authors:  A B Jaffe; L G Sharpe; J H Jaffe
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

2.  Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake.

Authors:  A Anghel; C A M Jamieson; X Ren; J Young; R Porche; E Ozigbo; D E Ghods; M L Lee; Y Liu; K Lutfy; T C Friedman
Journal:  Neuroscience       Date:  2010-02-06       Impact factor: 3.590

3.  Striatal regulation of morphine-induced hyperphagia: an anatomical mapping study.

Authors:  V P Bakshi; A E Kelley
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 4.  The effects of opioids and opioid analogs on animal and human endocrine systems.

Authors:  Cassidy Vuong; Stan H M Van Uum; Laura E O'Dell; Kabirullah Lutfy; Theodore C Friedman
Journal:  Endocr Rev       Date:  2009-11-10       Impact factor: 19.871

5.  Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake.

Authors:  Xiuhai Ren; Kabirullah Lutfy; Michael Mangubat; Monica G Ferrini; Martin L Lee; Yanjun Liu; Theodore C Friedman
Journal:  J Obes       Date:  2013-08-29
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.