AIMS: To test in a double-blinded, randomized trial whether the combination of electrically guided left ventricular (LV) lead placement and post-implant interventricular pacing delay (VVd) optimization results in superior increase in LV ejection fraction (LVEF) in cardiac resynchronization therapy (CRT) recipients. METHODS AND RESULTS: Stratified according to presence of ischaemic heart disease, 122 patients were randomized 1:1 to LV lead placement targeted towards the latest electrically activated segment identified by systematic mapping of the coronary sinus tributaries during CRT implantation combined with post-implant VVd optimization (intervention group) or imaging-guided LV lead implantation by cardiac computed tomography venography, 82Rubidium myocardial perfusion imaging and speckle tracking echocardiography targeting the LV lead towards the latest mechanically activated non-scarred myocardial segment (control group). Follow-up was 6 months. Primary endpoint was absolute increase in LVEF. Additional outcome measures were changes in New York Heart Association class, 6-minute walk test, and quality of life, LV reverse remodelling, and device related complications. Analysis was intention-to-treat. A larger increase in LVEF was observed in the intervention group (11 ± 10 vs. 7 ± 11%; 95% confidence interval 0.4-7.9%, P = 0.03); when adjusting for pre-specified baseline covariates this difference did not maintain statistical significance (P = 0.09). Clinical response, LV reverse remodelling, and complication rates did not differ between treatment groups. CONCLUSION:Electrically guided CRT implantation appeared non-inferior to an imaging-guided strategy considering the outcomes of change in LVEF, LV reverse remodelling and clinical response. Larger long-term studies are warranted to investigate the effect of an electrically guided CRT strategy. Published on behalf of the European Society of Cardiology. All rights reserved.
RCT Entities:
AIMS: To test in a double-blinded, randomized trial whether the combination of electrically guided left ventricular (LV) lead placement and post-implant interventricular pacing delay (VVd) optimization results in superior increase in LV ejection fraction (LVEF) in cardiac resynchronization therapy (CRT) recipients. METHODS AND RESULTS: Stratified according to presence of ischaemic heart disease, 122 patients were randomized 1:1 to LV lead placement targeted towards the latest electrically activated segment identified by systematic mapping of the coronary sinus tributaries during CRT implantation combined with post-implant VVd optimization (intervention group) or imaging-guided LV lead implantation by cardiac computed tomography venography, 82Rubidium myocardial perfusion imaging and speckle tracking echocardiography targeting the LV lead towards the latest mechanically activated non-scarred myocardial segment (control group). Follow-up was 6 months. Primary endpoint was absolute increase in LVEF. Additional outcome measures were changes in New York Heart Association class, 6-minute walk test, and quality of life, LV reverse remodelling, and device related complications. Analysis was intention-to-treat. A larger increase in LVEF was observed in the intervention group (11 ± 10 vs. 7 ± 11%; 95% confidence interval 0.4-7.9%, P = 0.03); when adjusting for pre-specified baseline covariates this difference did not maintain statistical significance (P = 0.09). Clinical response, LV reverse remodelling, and complication rates did not differ between treatment groups. CONCLUSION: Electrically guided CRT implantation appeared non-inferior to an imaging-guided strategy considering the outcomes of change in LVEF, LV reverse remodelling and clinical response. Larger long-term studies are warranted to investigate the effect of an electrically guided CRT strategy. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Juan M F Fernández; Damián N Spagnuolo; María T Politi; Iván A Tello Santacruz; Miguel Schiavone; César Cáceres Monié; Horacio A Avaca; Osvaldo Chara Journal: Sci Rep Date: 2022-06-15 Impact factor: 4.996
Authors: Justin Gould; Baldeep S Sidhu; Benjamin J Sieniewicz; Bradley Porter; Angela W C Lee; Orod Razeghi; Jonathan M Behar; Vishal Mehta; Mark K Elliott; Daniel Toth; Ulrike Haberland; Reza Razavi; Ronak Rajani; Steven Niederer; Christopher A Rinaldi Journal: J Cardiovasc Electrophysiol Date: 2021-02-10 Impact factor: 2.942
Authors: Manav Sohal; Shoaib Hamid; Giovanni Perego; Paolo Della Bella; Shaumik Adhya; John Paisey; Tim Betts; Ravi Kamdar; Pier Lambiase; Francisco Leyva; Janet M McComb; Jonathan Behar; Thomas Jackson; Simon Claridge; Vishal Mehta; Mark Elliott; Steven Niederer; Reza Razavi; C Aldo Rinaldi Journal: Heart Rhythm O2 Date: 2021-01-22