Literature DB >> 3127397

Comparison of DNA adducts in mouse and rat epidermis versus dermis after topical application of (+/-)r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene and (+/-) benzo(a)pyrene-4,5-oxide.

M Rojas1, K Alexandrov.   

Abstract

Mice and rats were treated topically with the BP metabolites, anti-BPDE and BPO. Rat epidermal DNA was extensively modified by BPO, while mouse epidermal DNA was preferentially modified by anti-BPDE. Anti-BPDE-dGuo adducts were observed only in mouse dermal DNA. DNA adducts were absent from the rat dermis. This adduct formation could be the reason for the very different in vivo biological effects of BP metabolites in the two species.

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Year:  1988        PMID： 3127397     DOI： 10.1007/bf00390496

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  8 in total

1.  In vivo formation and persistence of DNA adducts in mouse and rat skin exposed to (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

Authors:  M Rojas; K Alexandrov
Journal:  Carcinogenesis       Date:  1986-09       Impact factor: 4.944

2.  Double-stranded DNA steroselectively binds benzo(a)pyrene diol epoxides.

Authors:  T Meehan; K Straub
Journal:  Nature       Date:  1979-02-01       Impact factor: 49.962

Review 3.  Fifty years of benzo(a)pyrene.

Authors:  D H Phillips
Journal:  Nature       Date:  1983 Jun 9-15       Impact factor: 49.962

4.  Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,5- and 7,8-diol-9,10-epoxides and 7,8-diol.

Authors:  T J Slaga; A Viaje; D L Betty; W Brachen; S G Buty; J D Scribner
Journal:  Cancer Lett       Date:  1976-11       Impact factor: 8.679

5.  The reaction of (+/-)-7alpha, 8beta-dihydroxy-9beta, 10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA.

Authors:  M R Osborne; F A Beland; R G Harvey; P Brookes
Journal:  Int J Cancer       Date:  1976-09-15       Impact factor: 7.396

6.  In vivo formation and persistence of DNA and protein adducts in mouse and rat skin exposed to (+/-)benzo[a]pyrene-4,5-oxide.

Authors:  M Rojas; K Alexandrov
Journal:  Carcinogenesis       Date:  1986-02       Impact factor: 4.944

7.  Comparison of benzo[a]pyrene-DNA adduct levels in mouse and rat epidermis and dermis.

Authors:  M Rojas; W Baer-Dubowska; K Alexandrov
Journal:  Cancer Lett       Date:  1986-01       Impact factor: 8.679

8.  Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin.

Authors:  W Levin; A W Wood; H Yagi; P M Dansette; D M Jerina; A H Conney
Journal:  Proc Natl Acad Sci U S A       Date:  1976-01       Impact factor: 11.205
  8 in total

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