Yasmin El Dabagh1,2, Line Petersen3, Michael Pedersen4, Toke Bek3. 1. Department of Ophthalmology, Aarhus University Hospital, 8200, Aarhus N, Denmark. yasmin.eldabagh@clin.au.dk. 2. Comparative Medicine Laboratory, Department of Clinical Medicine, Aarhus University Hospital, 8200, Aarhus N, Denmark. yasmin.eldabagh@clin.au.dk. 3. Department of Ophthalmology, Aarhus University Hospital, 8200, Aarhus N, Denmark. 4. Comparative Medicine Laboratory, Department of Clinical Medicine, Aarhus University Hospital, 8200, Aarhus N, Denmark.
Abstract
PURPOSE: Remote ischemic conditioning (RIC) implies that transient ischemia in one organ can affect blood flow and protect from ischemia in another remote organ such as the retina. The purpose of the present study was to investigate the effect of RIC on the diameter of retinal arterioles in patients with diabetic retinopathy and whether this effect differs among peripheral and macular vessels. METHODS: In twenty type 1 diabetes patients aged 20-31 years, the Dynamic Vessel Analyzer (DVA) was used to measure diameters of peripheral and macular arterioles during rest, isometric exercise, and flicker stimulation. Measurements were obtained before, immediately after, and 1 h after RIC, and were compared to responses obtained from normal persons. RESULTS: The reduced baseline diameter (p < 0.009) and contraction of peripheral retinal arterioles during isometric exercise (p = 0.025) observed immediately after RIC in normal persons were absent in the studied diabetic patients. CONCLUSIONS: RIC affects the diameter of peripheral but not macular arterioles in normal persons, but the response is abolished in diabetic patients. TRIAL REGISTRATION: NCT03906383.
PURPOSE: Remote ischemic conditioning (RIC) implies that transient ischemia in one organ can affect blood flow and protect from ischemia in another remote organ such as the retina. The purpose of the present study was to investigate the effect of RIC on the diameter of retinal arterioles in patients with diabetic retinopathy and whether this effect differs among peripheral and macular vessels. METHODS: In twenty type 1 diabetespatients aged 20-31 years, the Dynamic Vessel Analyzer (DVA) was used to measure diameters of peripheral and macular arterioles during rest, isometric exercise, and flicker stimulation. Measurements were obtained before, immediately after, and 1 h after RIC, and were compared to responses obtained from normal persons. RESULTS: The reduced baseline diameter (p < 0.009) and contraction of peripheral retinal arterioles during isometric exercise (p = 0.025) observed immediately after RIC in normal persons were absent in the studied diabeticpatients. CONCLUSIONS: RIC affects the diameter of peripheral but not macular arterioles in normal persons, but the response is abolished in diabeticpatients. TRIAL REGISTRATION: NCT03906383.
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