Literature DB >> 31273451

Dampened X-chromosomes in human pluripotent stem cells: dampening or erasure of X-upregulation?

Harman Kaur1, Pavithra Rv1, Srimonta Gayen2.   

Abstract

The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of X-chromosome dampening in human naïve pluripotent stem cells (hPSCs) as well. Here, we discuss whether X-dampening reported in hPSCs truly reflects the dampening of X-chromosomes or it is a consequence of the erasure of X-chromosome upregulation.

Entities:  

Keywords:  Human embryos; Naive and primed pluripotency; X-chromosome dampening; X-chromosome inactivation; X-upregulation, human pluripotent stem cells; Xist

Mesh：

Year:  2019        PMID： 31273451     DOI： 10.1007/s00412-019-00717-5

Source DB:  PubMed          Journal:  Chromosoma        ISSN： 0009-5915            Impact factor:   4.316


  2 in total

1.  Single-Cell Analysis Reveals Partial Reactivation of X Chromosome instead of Chromosome-wide Dampening in Naive Human Pluripotent Stem Cells.

Authors:  Susmita Mandal; Deepshikha Chandel; Harman Kaur; Sudeshna Majumdar; Maniteja Arava; Srimonta Gayen
Journal:  Stem Cell Reports       Date:  2020-04-30       Impact factor: 7.765

Review 2.  Mechanisms of Choice in X-Chromosome Inactivation.

Authors:  Giulia Furlan; Rafael Galupa
Journal:  Cells       Date:  2022-02-03       Impact factor: 6.600
  2 in total

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