Amelia Grosso1, Giancarlo Pesce2, Alessandro Marcon3, Davide Piloni4, Federica Albicini4, Erica Gini4, Pierpaolo Marchetti3, Salvatore Battaglia5, Marcello Ferrari6, Alessandro Fois7, Pavilio Piccioni8, Leonardo Antonicelli9, Giuseppe Verlato3, Angelo Guido Corsico4. 1. Division of Respiratory Diseases, IRCCS "San Matteo" Hospital Foundation, University of Pavia, Pavia, Italy. Electronic address: amelia.grosso@gmail.com. 2. Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Unit of Epidemiology of Allergic and Respiratory Diseases (EPAR), F75012, Paris, France. 3. Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy. 4. Division of Respiratory Diseases, IRCCS "San Matteo" Hospital Foundation, University of Pavia, Pavia, Italy. 5. Department of Science and Promotion of Health and Maternal Infancy "G. D'Alessandro" (PROMISE), University of Palermo, Palermo, Italy. 6. Department of Medicine, Section of Respiratory Medicine, University of Verona, Verona, Italy. 7. Department of Clinical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. 8. Unit of Respiratory Medicine, National Health Service, ASL TO2, Torino, Italy. 9. Allergology Unit, University-Hospital, Ancona, Italy.
Abstract
BACKGROUND: Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population. METHODS: The data were collected in GEIRD, an Italian multicenter, population-based, multicase-control study. 2227 participants (age 21-86 years, female 50%) underwent standardized interviews, skin prick and lung function tests, and were divided into cases of current asthma (n = 528), rhinitis without asthma (n = 972), and controls (n = 727). Two specific questions from the Patient Health Questionnaire (PHQ-2) were asked to identify symptoms of depressed mood and anhedonia, which were used as a proxy of major depression disorder. RESULTS: The prevalence of depression was 16.7%, 11.9%, and 5.1% in subjects with asthma, rhinitis and controls, respectively. Both in asthma and rhinitis, subjects with depression had worse respiratory-health related quality of life and more frequent disease-related symptoms than their non-depressed counterparts. In asthma, depression was associated with poorer disease control. In rhinitis, depression was significantly associated with a disease-related limitations in daily activities and greater risk of symptom exacerbations and prescriptions of medicines for breathing. Cases of rhinitis with depression were less likely to be atopic. CONCLUSIONS: Our results suggest that rhinitis exacerbations, particularly in non-atopic subjects, and low asthma control are strongly related to the presence of depressed mood in adults from the general population.
BACKGROUND: Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population. METHODS: The data were collected in GEIRD, an Italian multicenter, population-based, multicase-control study. 2227 participants (age 21-86 years, female 50%) underwent standardized interviews, skin prick and lung function tests, and were divided into cases of current asthma (n = 528), rhinitis without asthma (n = 972), and controls (n = 727). Two specific questions from the Patient Health Questionnaire (PHQ-2) were asked to identify symptoms of depressed mood and anhedonia, which were used as a proxy of major depression disorder. RESULTS: The prevalence of depression was 16.7%, 11.9%, and 5.1% in subjects with asthma, rhinitis and controls, respectively. Both in asthma and rhinitis, subjects with depression had worse respiratory-health related quality of life and more frequent disease-related symptoms than their non-depressed counterparts. In asthma, depression was associated with poorer disease control. In rhinitis, depression was significantly associated with a disease-related limitations in daily activities and greater risk of symptom exacerbations and prescriptions of medicines for breathing. Cases of rhinitis with depression were less likely to be atopic. CONCLUSIONS: Our results suggest that rhinitis exacerbations, particularly in non-atopic subjects, and low asthma control are strongly related to the presence of depressed mood in adults from the general population.
Authors: Jonathan M Feldman; Jacqueline Becker; Arushi Arora; Jesenya DeLeon; Tatiana Torres-Hernandez; Naomi Greenfield; Allyana Wiviott; Sunit Jariwala; Chang Shim; Alex D Federman; Juan P Wisnivesky Journal: Psychosom Med Date: 2021-09-01 Impact factor: 3.864
Authors: Johanna Karlsson Sundbaum; Jon R Konradsen; Lowie E G W Vanfleteren; Sten Axelsson Fisk; Christophe Pedroletti; Yvonne Sjöö; Jörgen Syk; Therese Sterner; Anne Lindberg; Alf Tunsäter; Fredrik Nyberg; Ann Ekberg-Jansson; Caroline Stridsman Journal: Ther Adv Respir Dis Date: 2022 Jan-Dec Impact factor: 5.158
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