Philipp Koehler1,2, Maiken Cavling Arendrup3,4,5, Sevtap Arikan-Akdagli6, Matteo Bassetti7, Stéphane Bretagne8, Lena Klingspor9, Katrien Lagrou10,11, Jacques F Meis12, Riina Rautemaa-Richardson13,14, Silke Schelenz15, Axel Hamprecht16, Felix C Koehler2,17, Oliver Kurzai18,19, Jon Salmanton-García1, Jörg-Janne Vehreschild1,20,21, Alexandre Alanio8, Ana Alastruey-Izquierdo22, Valentina Arsic Arsenijevic23, Jean-Pierre Gangneux24, Neil A R Gow25, Suzana Hadina26, Petr Hamal27,28, Elizabeth Johnson29, Nikolay Klimko30, Cornelia Lass-Flörl31, Mihai Mares32, Volkan Özenci33,34, Tamas Papp35, Emmanuel Roilides36, Raquel Sabino37, Esther Segal38, Alida Fe Talento39,40,41, Anna Maria Tortorano42, Paul E Verweij43, Martin Hoenigl44,45, Oliver A Cornely1,2,21,46. 1. Faculty of Medicine, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany. 2. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. 3. Unit of Mycology, Statens Serum Institute, Copenhagen, Denmark. 4. Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark. 5. Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. 6. Department of Medical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey. 7. Department of Medicine, Infectious Diseases Clinic, University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy. 8. Parasitology-Mycology Laboratory, Lariboisière Saint-Louis Fernand Widal Hospitals, Assistance Publique-Hôpitaux de Paris (APHP), Molecular Mycology Unit, CNRS, UMR2000, Institut Pasteur, Université de Paris, Paris, France. 9. Department of Laboratory Medicine, Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. 10. Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology, Immunology and Transplantation, Excellence Center for Medical Mycology (ECMM), KU Leuven, Leuven, Belgium. 11. Department of Laboratory Medicine and National Reference Center for Mycosis, Excellence Center for Medical Mycology (ECMM), University Hospitals Leuven, Leuven, Belgium. 12. Department of Medical Microbiology and Infectious Diseases, Excellence Center for Medical Mycology (ECMM), Center of Expertise in Mycology Radboudumc/CWZ, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. 13. Department of Infectious Diseases and Mycology Reference Centre Manchester, Manchester University NHS Foundation Trust, Manchester, UK. 14. Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. 15. Department of Microbiology, Royal Brompton Hospital, London, UK. 16. Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, Cologne, Germany. 17. Faculty of Medicine, Department II of Internal Medicine, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. 18. National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany. 19. Institute for Hygiene and Microbiology, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany. 20. Center for Internal Medicine, Hematology and Oncology, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany. 21. German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany. 22. National Centre for Micobiology, Instituto de Salud Carlos III, Madrid, Spain. 23. National Reference Medical Mycology Laboratory, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade, Belgrade, Serbia. 24. Institut de Recherche en Santé, Environnement et travail, Inserm, CHU de Rennes, EHESP, UMR_S 1085, Université de Rennes, Rennes, France. 25. School of Biosciences, University of Exeter, Exeter, UK. 26. Department of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia. 27. Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia. 28. University Hospital Olomouc, Olomouc, Czechia. 29. Public Health England Mycology Reference Laboratory, National Infection Services, PHE South West Laboratory, Science Quarter, Southmead Hospital, Southmead, Bristol, UK. 30. Department of Clinical Mycology, Allergy and Immunology, North Western State Medical University, Saint Petersburg, Russia. 31. Division of Hygiene and Medical Microbiology, Excellence Center for Medical Mycology (ECMM), Medical University of Innsbruck, Innsbruck, Austria. 32. Laboratory of Antimicrobial Chemotherapy, Ion Ionescu de la Brad University, Iași, Romania. 33. Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. 34. Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. 35. MTA-SZTE Fungal Pathogenicity Mechanisms Research Group, Department of Microbiology, University of Szeged, Szeged, Hungary. 36. Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Medicine, Hippokration General Hospital, Aristotle University School of Health Sciences, Thessaloniki, Greece. 37. Department of Infectious Diseases, Nacional Institute of Health Dr. Ricardo Jorge - Reference Unit for Parasitic and Fungal Infections, Lisbon, Portugal. 38. Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 39. Department of Clinical Microbiology, Royal College of Surgeons Ireland, Dublin, Ireland. 40. Microbiology Department, Our Lady of Lourdes Hospital, Drogheda, Ireland. 41. Department of Microbiology, Beaumont Hospital, Dublin 9, Ireland. 42. Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy. 43. Department of Medical Microbiology, Excellence Center for Medical Mycology (ECMM), Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands. 44. Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria. 45. Division of Infectious Diseases, Department of Medicine, UCSD, San Diego, California. 46. Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.
Abstract
BACKGROUND: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. OBJECTIVES: Triggered by the emergence of C auris and by increasing antifungal resistance rates the European Confederation of Medical Mycology developed an international Candida Registry (FungiScope™ CandiReg) to allow contemporary multinational surveillance. METHODS: CandiReg serves as platform for international cooperation to enhance research regarding invasive Candida infections. CandiReg uses the General Data Protection Regulation compliant data platform ClinicalSurveys.net that holds the electronic case report forms (eCRF). Data entry is supported via an interactive macro created by the software that can be accessed via any Internet browser. RESULTS: CandiReg provides an eCRF for invasive Candida infections that can be used for a variety of studies from cohort studies on attributable mortality to evaluations of guideline adherence, offering to the investigators of the 28 ECMM member countries the opportunity to document their cases of invasive Candida infection. CandiReg allows the monitoring of epidemiology of invasive Candida infections, including monitoring of multinational outbreaks. Here, we describe the structure and management of the CandiReg platform. CONCLUSION: CandiReg supports the collection of clinical information and isolates to improve the knowledge on epidemiology and eventually to improve management of invasive Candida infections. CandiReg promotes international collaboration, improving the availability and quality of evidence on invasive Candida infection and contributes to improved patient management.
BACKGROUND: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. OBJECTIVES: Triggered by the emergence of C auris and by increasing antifungal resistance rates the European Confederation of Medical Mycology developed an international Candida Registry (FungiScope™ CandiReg) to allow contemporary multinational surveillance. METHODS: CandiReg serves as platform for international cooperation to enhance research regarding invasive Candida infections. CandiReg uses the General Data Protection Regulation compliant data platform ClinicalSurveys.net that holds the electronic case report forms (eCRF). Data entry is supported via an interactive macro created by the software that can be accessed via any Internet browser. RESULTS: CandiReg provides an eCRF for invasive Candida infections that can be used for a variety of studies from cohort studies on attributable mortality to evaluations of guideline adherence, offering to the investigators of the 28 ECMM member countries the opportunity to document their cases of invasive Candida infection. CandiReg allows the monitoring of epidemiology of invasive Candida infections, including monitoring of multinational outbreaks. Here, we describe the structure and management of the CandiReg platform. CONCLUSION: CandiReg supports the collection of clinical information and isolates to improve the knowledge on epidemiology and eventually to improve management of invasive Candida infections. CandiReg promotes international collaboration, improving the availability and quality of evidence on invasive Candida infection and contributes to improved patient management.
Authors: Kai-Manuel Adam; Michael Osthoff; Frédéric Lamoth; Anna Conen; Véronique Erard; Katia Boggian; Peter W Schreiber; Stefan Zimmerli; Pierre-Yves Bochud; Dionysios Neofytos; Mapi Fleury; Hans Fankhauser; Daniel Goldenberger; Konrad Mühlethaler; Arnaud Riat; Reinhard Zbinden; Andreas Kronenberg; Chantal Quiblier; Oscar Marchetti; Nina Khanna Journal: Open Forum Infect Dis Date: 2021-09-17 Impact factor: 3.835