| Literature DB >> 3127059 |
V P Sukhatme1, X M Cao, L C Chang, C H Tsai-Morris, D Stamenkovich, P C Ferreira, D R Cohen, S A Edwards, T B Shows, T Curran.
Abstract
Egr-1 is an early growth response gene that displays fos-like induction kinetics in fibroblasts, epithelial cells, and lymphocytes following mitogenic stimulation. Sequence analysis of murine Egr-1 cDNA predicts a protein with three DNA binding zinc fingers. The human EGR1 gene maps to chromosome 5 (bands 5q23-31). Egr-1 mRNA increases dramatically during cardiac and neural cell differentiation, and following membrane depolarization both in vitro and in vivo. Thus, Egr-1 and c-fos are often coregulated with strikingly similar kinetics. These results, in conjunction with the Egr-1 primary structure, suggest that Egr-1 may function as a transcriptional regulator in diverse biological processes.Entities:
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Year: 1988 PMID： 3127059 DOI： 10.1016/0092-8674(88)90485-0
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582