Literature DB >> 31269458

From Molecular Understanding to Organismal Biology of N-Terminal Acetyltransferases.

Gholson J Lyon1.   

Abstract

In this issue of Structure, Deng et al. (2019) determine the structure of the yeast N-terminal acetyltransferases Naa10 and Naa50 in complex with Naa15 and demonstrate that Naa50 has negligible catalytic activity on its own but modulates Naa10/Naa15. This study provides insights into mechanisms involving amino-terminal acetylation of proteins.
Copyright © 2019 Elsevier Ltd. All rights reserved.

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Year:  2019        PMID： 31269458      PMCID： PMC7313478          DOI： 10.1016/j.str.2019.06.002

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  10 in total

1.  Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.

Authors:  Sunbin Deng; Robert S Magin; Xuepeng Wei; Buyan Pan; E James Petersson; Ronen Marmorstein
Journal:  Structure       Date:  2019-05-30       Impact factor: 5.006

Review 2.  Structure and mechanism of non-histone protein acetyltransferase enzymes.

Authors:  David R Friedmann; Ronen Marmorstein
Journal:  FEBS J       Date:  2013-06-28       Impact factor: 5.542

3.  N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.

Authors:  Petra Van Damme; Kristine Hole; Kris Gevaert; Thomas Arnesen
Journal:  Proteomics       Date:  2015-06-05       Impact factor: 3.984

Review 4.  Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.

Authors:  Henriette Aksnes; Rasmus Ree; Thomas Arnesen
Journal:  Mol Cell       Date:  2019-03-13       Impact factor: 17.970

5.  The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides.

Authors:  Matthias Gautschi; Sören Just; Andrej Mun; Suzanne Ross; Peter Rücknagel; Yves Dubaquié; Ann Ehrenhofer-Murray; Sabine Rospert
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

6.  Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.

Authors:  Leah Gottlieb; Ronen Marmorstein
Journal:  Structure       Date:  2018-05-10       Impact factor: 5.006

7.  Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15.

Authors:  Hanyin Cheng; Leah Gottlieb; Elaine Marchi; Robert Kleyner; Puja Bhardwaj; Alan F Rope; Sarah Rosenheck; Sébastien Moutton; Christophe Philippe; Wafaa Eyaid; Fowzan S Alkuraya; Janet Toribio; Rafael Mena; Carlos E Prada; Holly Stessman; Raphael Bernier; Marieke Wermuth; Birgit Kauffmann; Bettina Blaumeiser; R Frank Kooy; Diana Baralle; Grazia M S Mancini; Simon J Conway; Fan Xia; Zhao Chen; Linyan Meng; Ljubisa Mihajlovic; Ronen Marmorstein; Gholson J Lyon
Journal:  Hum Mol Genet       Date:  2019-09-01       Impact factor: 6.150

8.  Loss of amino-terminal acetylation suppresses a prion phenotype by modulating global protein folding.

Authors:  William M Holmes; Brian K Mannakee; Ryan N Gutenkunst; Tricia R Serio
Journal:  Nat Commun       Date:  2014-07-15       Impact factor: 14.919

Review 9.  NAA10-related syndrome.

Authors:  Yiyang Wu; Gholson J Lyon
Journal:  Exp Mol Med       Date:  2018-07-27       Impact factor: 8.718

10.  Molecular basis for N-terminal acetylation by the heterodimeric NatA complex.

Authors:  Glen Liszczak; Jacob M Goldberg; Håvard Foyn; E James Petersson; Thomas Arnesen; Ronen Marmorstein
Journal:  Nat Struct Mol Biol       Date:  2013-08-04       Impact factor: 15.369
  10 in total
  1 in total

1.  Variants in NAA15 cause pediatric hypertrophic cardiomyopathy.

Authors:  Alyssa Ritter; Justin H Berger; Matthew Deardorff; Kosuke Izumi; Kimberly Y Lin; Livija Medne; Rebecca C Ahrens-Nicklas
Journal:  Am J Med Genet A       Date:  2020-10-26       Impact factor: 2.802
  1 in total

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