| Literature DB >> 31264539 |
Brenna L C Gondim1,2, João A Oshiro-Júnior1, Felipe H A Fernanandes1, Fernanda P Nóbrega1, Lúcio R C Castellano2, Ana C D Medeiros1.
Abstract
BACKGROUND: Plant extracts loaded in nanostructured drug delivery systems (NDDSs) have been reported as an alternative to current therapies for treating parasitic and antimicrobial diseases. Among their advantages, plant extracts in NDSSs increase the stability of the drugs against environmental factors by promoting protection against oxygen, humidity, and light, among other factors; improve the solubility of hydrophobic compounds; enhance the low absorption of the active components of the extracts (i.e., biopharmaceutical classification II), which results in greater bioavailability; and control the release rate of the substances, which is fundamental to improving the therapeutic effectiveness. In this review, we present the most recent data on NDDSs using plant extracts and report results obtained from studies related to in vitro and in vivo biological activities. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Parasitic and antimicrobial resistance; environmental factors; inzzm321990vivo; in vitro; nanostructured drug delivery systems; plant extracts.
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Year: 2019 PMID： 31264539 DOI： 10.2174/1381612825666190628153755
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116