Francesca Luzzati1, Emanuele Maria Giusti2,3, Gennaro Maria Scotto1, Giuseppe Perrucchini1, Luca Cannavò1, Gianluca Castelnuovo4,5, Andrea Colonna Cottini1. 1. IRCCS Orthopedic Institute Galeazzi, Milan, Italy. 2. Catholic University of Milan, Department of Psychology, Milan, Italy. emanuelemaria.giusti@unicatt.it. 3. Istituto Auxologico Italiano IRCCS, Psychology Research Laboratory, San Giuseppe Hospital, Verbania, Italy. emanuelemaria.giusti@unicatt.it. 4. Catholic University of Milan, Department of Psychology, Milan, Italy. 5. Istituto Auxologico Italiano IRCCS, Psychology Research Laboratory, San Giuseppe Hospital, Verbania, Italy.
Abstract
PURPOSE: Knowledge about quality of life (QOL), pain, and psychological factors in patients with primary tumors of the spine is limited, but is important in planning rehabilitation after surgery. Aims of this study were to assess the preoperative levels and improvement after surgery of these factors, and to identify the predictors of postoperative pain and QOL. METHODS: Patients with primary tumors undergoing spine surgery were matched for sex and age with patients with metastatic tumors. QOL was measured at baseline and three months after surgery with the physical (PCS) and mental (MCS) components SF-12 subscales, pain intensity with a numeric rating scale (NRS), depression with the Beck Depression Inventory (BDI). Preoperative SF-12, NRS, and BDI levels and differences in follow-up improvement in SF-12 and NRS were compared across samples. LASSO regressions were performed to find predictors of follow-up SF-12 and NRS. RESULTS: Patients with primary tumors showed better PCS and NRS, and similar BDI and MCS than patients with metastatic tumors. At follow-up, they showed stronger improvement in the MCS and no improvement in the PCS. All QOL scores were below those of the general population. Follow-up PCS was predicted by baseline PCS and BDI; MCS by baseline MCS; pain intensity by baseline pain intensity and BDI. CONCLUSION: Patients with primary tumors of the spine suffer from moderate levels of physical and mental impairment. Depression influences surgical outcomes.
PURPOSE: Knowledge about quality of life (QOL), pain, and psychological factors in patients with primary tumors of the spine is limited, but is important in planning rehabilitation after surgery. Aims of this study were to assess the preoperative levels and improvement after surgery of these factors, and to identify the predictors of postoperative pain and QOL. METHODS:Patients with primary tumors undergoing spine surgery were matched for sex and age with patients with metastatic tumors. QOL was measured at baseline and three months after surgery with the physical (PCS) and mental (MCS) components SF-12 subscales, pain intensity with a numeric rating scale (NRS), depression with the Beck Depression Inventory (BDI). Preoperative SF-12, NRS, and BDI levels and differences in follow-up improvement in SF-12 and NRS were compared across samples. LASSO regressions were performed to find predictors of follow-up SF-12 and NRS. RESULTS:Patients with primary tumors showed better PCS and NRS, and similar BDI and MCS than patients with metastatic tumors. At follow-up, they showed stronger improvement in the MCS and no improvement in the PCS. All QOL scores were below those of the general population. Follow-up PCS was predicted by baseline PCS and BDI; MCS by baseline MCS; pain intensity by baseline pain intensity and BDI. CONCLUSION:Patients with primary tumors of the spine suffer from moderate levels of physical and mental impairment. Depression influences surgical outcomes.
Entities:
Keywords:
Pain; Quality of life; Rehabilitation; Risk factors; Spine tumors; Surgery
Authors: Edward Chow; Keyue Ding; Wendy R Parulekar; Rebecca K S Wong; Yvette M van der Linden; Daniel Roos; William F Hartsell; Peter Hoskin; Jackson S Y Wu; Abdenour Nabid; Francisca Ong; Geertjan van Tienhoven; Scott Babington; William F Demas; Carolyn F Wilson; Michael Brundage; Liting Zhu; Ralph M Meyer Journal: Support Care Cancer Date: 2015-09-23 Impact factor: 3.603
Authors: Kathleen G Hopkins; Leslie A Hoffman; Annette De Vito Dabbs; Peter F Ferson; Linda King; Linda A Dudjak; Thomas G Zullo; Margaret Q Rosenzweig Journal: J Adv Pract Oncol Date: 2015-03-01