Özden Savaş1, Ahmet Emre Süslü2, Incilay Lay3, Serdar Özer2. 1. Department of Otolaryngology, Yüksekova State Hospital, Ipekyolu Street, District of Inanli Village, 30300, Yüksekova, Hakkari, Turkey. ozdensavas1@gmail.com. 2. Department of Otolaryngology, Hacettepe University Hospitals, 06100, Sihhiye, Ankara, Turkey. 3. Department of Biochemistry, Hacettepe University Hospitals, 06100, Sihhiye, Ankara, Turkey.
Abstract
PURPOSE: The relationship of plasma malondialdehyde (MDA) with major parameters of PSG was investigated to find out if there was a correlation between these variables. METHODS: Polysomnograms were done on a total of 37 adults who do not have a history of any systemic illness, smoking, and supplement use. Plasma MDA measurements and their relationship with PSG parameters were analyzed. RESULTS: The mean MDA concentrations in patients with lower AHI values were also lower than those in the patients with higher AHI (p < 0.001). Higher predominance of apnea in patients with similar AHI values, longer mean apnea durations, O2 saturation dips to < 90%, and higher ODI values predicted higher plasma MDA concentrations. CONCLUSIONS: Higher oxidative stress measurements predicted more severe clinical picture. These findings show that oxidative stress measurement with MDA may provide a simple tool to screen patients for OSA and help select them for PSG study appropriately, if indicated.
PURPOSE: The relationship of plasma malondialdehyde (MDA) with major parameters of PSG was investigated to find out if there was a correlation between these variables. METHODS: Polysomnograms were done on a total of 37 adults who do not have a history of any systemic illness, smoking, and supplement use. Plasma MDA measurements and their relationship with PSG parameters were analyzed. RESULTS: The mean MDA concentrations in patients with lower AHI values were also lower than those in the patients with higher AHI (p < 0.001). Higher predominance of apnea in patients with similar AHI values, longer mean apnea durations, O2 saturation dips to < 90%, and higher ODI values predicted higher plasma MDA concentrations. CONCLUSIONS: Higher oxidative stress measurements predicted more severe clinical picture. These findings show that oxidative stress measurement with MDA may provide a simple tool to screen patients for OSA and help select them for PSG study appropriately, if indicated.
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