Olli Helminen1, Eero Sihvo1, Jarmo Gunn2, Jussi O T Sipilä3,4, Päivi Rautava5,6, Ville Kytö2,7. 1. Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland. 2. Heart Center, Turku University Hospital, University of Turku, Turku, Finland. 3. Department of Neurology, North Karelia Central Hospital, Joensuu, Finland. 4. Division of Clinical Neurosciences, University of Turku, Turku, Finland. 5. Clinical Research Center, Turku University Hospital, Turku, Finland. 6. Department of Public Health, University of Turku, Turku, Finland. 7. Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Abstract
OBJECTIVES: Few population-based studies reporting trends in oesophageal cancer surgery exist. The aim of this study was to assess the incidence of oesophageal cancer, changes in resection rates, patient demographics and short- and long-term outcomes of oesophagectomy at the population level in Finland. METHODS: All Finnish patients diagnosed with cancer of the oesophagus or gastrooesophageal junction between 1 January 2004 and 31 December 2014 identified from the nationwide registries were included. The follow-up ended on 31 December 2016. For evaluation of changes in demographics and treatment, data were divided into 2 periods: 2004-2009 and 2010-2014. For comparison of short-and long-term outcomes, adjustments for age, sex, comorbidity, tumour stage and histology were used. RESULTS: The number of diagnosed oesophageal cancers was 4266. Of these, 740 underwent oesophagectomy. Resection rate increased from 15.2% in 2004-2009 to 19.6% in 2010-2014. The median number of oesophagectomies in Finnish hospitals increased from 1.9 to 3.7 per hospital per year. At the same time, minimally invasive surgery became more common (6.3% vs 35.1%, P < 0.0001) and a trend for increase in neoadjuvant treatment was observed (46.8% vs 53.8%, P = 0.0582). The rate of type III anastomosis leaks and conduit necroses was 5.1% without differences in time periods. Three-year [52.4% vs 61.6%, adjusted hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.59-0.95] and 5-year survival (42.1% vs 56.5%, adjusted HR 0.70, 95% CI 0.57-0.87) improved. CONCLUSIONS: This nationwide population-based study demonstrates an increase in resection rate, use of neoadjuvant treatment and minimally invasive surgery together with an improvement in long-term outcome after oesophageal cancer surgery.
OBJECTIVES: Few population-based studies reporting trends in oesophageal cancer surgery exist. The aim of this study was to assess the incidence of oesophageal cancer, changes in resection rates, patient demographics and short- and long-term outcomes of oesophagectomy at the population level in Finland. METHODS: All Finnish patients diagnosed with cancer of the oesophagus or gastrooesophageal junction between 1 January 2004 and 31 December 2014 identified from the nationwide registries were included. The follow-up ended on 31 December 2016. For evaluation of changes in demographics and treatment, data were divided into 2 periods: 2004-2009 and 2010-2014. For comparison of short-and long-term outcomes, adjustments for age, sex, comorbidity, tumour stage and histology were used. RESULTS: The number of diagnosed oesophageal cancers was 4266. Of these, 740 underwent oesophagectomy. Resection rate increased from 15.2% in 2004-2009 to 19.6% in 2010-2014. The median number of oesophagectomies in Finnish hospitals increased from 1.9 to 3.7 per hospital per year. At the same time, minimally invasive surgery became more common (6.3% vs 35.1%, P < 0.0001) and a trend for increase in neoadjuvant treatment was observed (46.8% vs 53.8%, P = 0.0582). The rate of type III anastomosis leaks and conduit necroses was 5.1% without differences in time periods. Three-year [52.4% vs 61.6%, adjusted hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.59-0.95] and 5-year survival (42.1% vs 56.5%, adjusted HR 0.70, 95% CI 0.57-0.87) improved. CONCLUSIONS: This nationwide population-based study demonstrates an increase in resection rate, use of neoadjuvant treatment and minimally invasive surgery together with an improvement in long-term outcome after oesophageal cancer surgery.
Authors: Henna Saviaro; Jukka Rintala; Joonas H Kauppila; Fredrik Yannopoulos; Sanna Meriläinen; Vesa Koivukangas; Heikki Huhta; Olli Helminen; Juha Saarnio Journal: J Thorac Dis Date: 2021-08 Impact factor: 3.005
Authors: Olli Helminen; Joonas H Kauppila; Henna Saviaro; Fredrik Yannopoulos; Sanna Meriläinen; Vesa Koivukangas; Heikki Huhta; Johanna Mrena; Juha Saarnio; Eero Sihvo Journal: J Thorac Dis Date: 2021-11 Impact factor: 2.895