| Literature DB >> 3126375 |
T Kawase1, I Ishikawa, A Suzuki.
Abstract
The sensitivity of fibroblasts (L cells) to low concentrations of sodium fluoride (NaF) was examined using the same cell during a series of stimuli. NaF with increasing concentrations up to 1 mM elevated cytosolic free Ca2+ concentrations ([Ca2+]i) in single cells. [Ca2+]i increased within 15 sec of addition of NaF and lowered to basal [Ca2+]i levels quickly. This elevation was observed both in the presence and absence of external Ca2+ and was enhanced by 1 microM Al3+. These results suggest that low concentrations (below 1 mM) of NaF induce Ca2+ release from intracellular Ca2+ stores in single L cells through guanine nucleotide-binding protein (G protein).Entities:
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Year: 1988 PMID： 3126375 DOI： 10.1016/0024-3205(88)90557-7
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037