Sarah R Tritsch1,2, Liliana Encinales1,2, Nelly Pacheco1,2, Andres Cadena1,2, Carlos Cure1,2, Elizabeth McMahon1,2, Hugh Watson1,2, Alexandra Porras Ramirez1,2, Alejandro Rico Mendoza1,2, Guangzhao Li1,2, Kunal Khurana1,2, Juan Jose Jaller-Raad1,2, Stella Mejia Castillo1,2, Onaldo Barrios Taborda1,2, Alejandro Jaller-Char1,2, Lil Avendaño Echavez1,2, Dennys Jiménez1,2, Andres Gonzalez Coba1,2, Magda Alarcon Gomez1,2, Dores Ariza Orozco1,2, Eyda Bravo1,2, Victor Martinez1,2, Brenda Guerra1,2, Gary Simon1,2, Gary S Firestein1,2, Aileen Y Chang3,4. 1. From George Washington University; George Mason University, Washington, DC; University of California, San Diego, San Diego, California, USA; Allied Research Society LLC; Clinica de La Costa Ltda.; Biomelab; Centro de Reumatología y Ortopedia; Universidad Simón Bolívar, Barranquilla, Atlántico; Universidad El Bosque, Bogotá, Colombia; Evotec ID, Lyon, France. 2. S.R. Tritsch, MS, George Washington University; L. Encinales, MD, Allied Research Society LLC; N. Pacheco, Allied Research Society LLC; A. Cadena, MD, Clinica de La Costa Ltda.; C. Cure, MD, Biomelab; E. McMahon, George Washington University; H. Watson, PhD, Evotec ID; A. Porras Ramirez, PhD, Universidad El Bosque; A.R. Mendoza, PhD, Universidad El Bosque; G. Li, MS, George Washington University; K. Khurana, George Mason University; J.J. Jaller-Raad, MD, Centro de Reumatología y Ortopedia; S. Mejia Castillo, MD, Universidad Simón Bolívar; O. Barrios Taborda, MD, Universidad Simón Bolívar; J.J. Jaller-Char, MD, Centro de Reumatología y Ortopedia; L. Avendaño Echavez, MD, Universidad Simón Bolívar; D. Jiménez, MD, Clinica de La Costa Ltda.; A. Gonzalez Coba, MD, Clinica de La Costa Ltda.; M. Alarcon Gomez, MD, Universidad Simón Bolívar; D. Ariza Orozco, Allied Research Society LLC; E. Bravo, Allied Research Society LLC; V. Martinez, Clinica de La Costa Ltda.; B. Guerra, Clinica de La Costa Ltda.; G. Simon, MD, PhD, George Washington University; G.S. Firestein, MD, ScD, University of California, San Diego; A.Y. Chang, MD, MSPH, George Washington University. 3. From George Washington University; George Mason University, Washington, DC; University of California, San Diego, San Diego, California, USA; Allied Research Society LLC; Clinica de La Costa Ltda.; Biomelab; Centro de Reumatología y Ortopedia; Universidad Simón Bolívar, Barranquilla, Atlántico; Universidad El Bosque, Bogotá, Colombia; Evotec ID, Lyon, France. chang@email.gwu.edu. 4. S.R. Tritsch, MS, George Washington University; L. Encinales, MD, Allied Research Society LLC; N. Pacheco, Allied Research Society LLC; A. Cadena, MD, Clinica de La Costa Ltda.; C. Cure, MD, Biomelab; E. McMahon, George Washington University; H. Watson, PhD, Evotec ID; A. Porras Ramirez, PhD, Universidad El Bosque; A.R. Mendoza, PhD, Universidad El Bosque; G. Li, MS, George Washington University; K. Khurana, George Mason University; J.J. Jaller-Raad, MD, Centro de Reumatología y Ortopedia; S. Mejia Castillo, MD, Universidad Simón Bolívar; O. Barrios Taborda, MD, Universidad Simón Bolívar; J.J. Jaller-Char, MD, Centro de Reumatología y Ortopedia; L. Avendaño Echavez, MD, Universidad Simón Bolívar; D. Jiménez, MD, Clinica de La Costa Ltda.; A. Gonzalez Coba, MD, Clinica de La Costa Ltda.; M. Alarcon Gomez, MD, Universidad Simón Bolívar; D. Ariza Orozco, Allied Research Society LLC; E. Bravo, Allied Research Society LLC; V. Martinez, Clinica de La Costa Ltda.; B. Guerra, Clinica de La Costa Ltda.; G. Simon, MD, PhD, George Washington University; G.S. Firestein, MD, ScD, University of California, San Diego; A.Y. Chang, MD, MSPH, George Washington University. chang@email.gwu.edu.
Abstract
OBJECTIVE: To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus (CHIKV) in a Latin American cohort. METHODS: A cross-sectional followup of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having CHIKV during the 2014-2015 epidemic, and baseline and followup symptoms at 40 months were evaluated in serologically confirmed cases. RESULTS: Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for CHIKV infection had persistent joint pain 3 years after infection. Participants who followed up in person were predominantly adult (mean ± SD age 51 ± 14 yrs) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness. CONCLUSION: To our knowledge, this is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunya joint pain and rheumatoid arthritis.
OBJECTIVE: To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus (CHIKV) in a Latin American cohort. METHODS: A cross-sectional followup of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having CHIKV during the 2014-2015 epidemic, and baseline and followup symptoms at 40 months were evaluated in serologically confirmed cases. RESULTS: Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for CHIKV infectionhad persistent joint pain 3 years after infection. Participants who followed up in person were predominantly adult (mean ± SD age 51 ± 14 yrs) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness. CONCLUSION: To our knowledge, this is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunyajoint pain and rheumatoid arthritis.
Authors: Aileen Y Chang; Karen A O Martins; Liliana Encinales; St Patrick Reid; Marlon Acuña; Carlos Encinales; Christian B Matranga; Nelly Pacheco; Carlos Cure; Bhavarth Shukla; Teofilo Ruiz Arteta; Richard Amdur; Lisa H Cazares; Melissa Gregory; Michael D Ward; Alexandra Porras; Alejandro Rico Mendoza; Lian Dong; Tara Kenny; Ernie Brueggemann; Lydia G Downey; Priyanka Kamalapathy; Paola Lichtenberger; Orlando Falls; Gary L Simon; Jeffrey M Bethony; Gary S Firestein Journal: Arthritis Rheumatol Date: 2018-03-07 Impact factor: 10.995
Authors: Juan C Rueda; Ana M Santos; Jose-Ignacio Angarita; Rodrigo B Giraldo; Eugenia-Lucia Saldarriaga; Jesús Giovanny Ballesteros Muñoz; Elías Forero; Hugo Valencia; Francisco Somoza; Daniel Martin-Arsanios; Elias-Josué Quintero; Viviana Reyes-Martinez; Diana Padilla; Francy M Cuervo; Ingris Peláez-Ballestas; Mario H Cardiel; Paula X Pavía; John Londono Journal: Emerg Microbes Infect Date: 2019 Impact factor: 7.163
Authors: Doris K Nyamwaya; Mark Otiende; Donwilliams O Omuoyo; George Githinji; Henry K Karanja; John N Gitonga; Zaydah R de Laurent; James R Otieno; Rosemary Sang; Everlyn Kamau; Stanley Cheruiyot; Edward Otieno; Charles N Agoti; Philip Bejon; Samuel M Thumbi; George M Warimwe Journal: BMC Infect Dis Date: 2021-02-18 Impact factor: 3.090
Authors: Karol Suchowiecki; St Patrick Reid; Gary L Simon; Gary S Firestein; Aileen Chang Journal: Curr Rheumatol Rep Date: 2021-04-13 Impact factor: 4.592
Authors: Hugh Watson; Ramão Luciano Nogueira-Hayd; Maony Rodrigues-Moreno; Felipe Naveca; Giulia Calusi; Karol Suchowiecki; Gary S Firestein; Gary Simon; Aileen Y Chang Journal: Sci Rep Date: 2021-09-17 Impact factor: 4.379
Authors: Dominic Paquin-Proulx; Bronwyn M Gunn; Aljawharah Alrubayyi; Danielle V Clark; Matthew Creegan; Dohoon Kim; Hannah Kibuuka; Monica Millard; Salim Wakabi; Leigh Anne Eller; Nelson L Michael; Randal J Schoepp; Matthew J Hepburn; Lisa E Hensley; Merlin L Robb; Galit Alter; Michael A Eller Journal: Front Immunol Date: 2021-05-20 Impact factor: 7.561
Authors: Sarah R Tritsch; Richard Amdur; Liliana Encinales; Andres Cadena; Paige Fierbaugh; Geraldine Avendaño; Carlos Andres Herrera Gomez; Karol Suchowiecki; Evelyn Mendoza-Torres; Wendy Rosales; Dennys Jimenez; Carlos Alberto Perez Hernandez; Alfonso Sucerquia Hernandez; Paula Bruges Silvera; Yerlenis Galvis Crespo; Alberto David Cabana Jimenez; Jennifer Carolina Martinez Zapata; Christopher N Mores; Gary S Firestein; Gary Simon; Aileen Y Chang Journal: J Cell Immunol Date: 2021