Literature DB >> 31262766

Patient-Derived Cytomegaloviruses with Different Ganciclovir Sensitivities from UL97 Mutation Retain Their Replication Efficiency and Some Kinase Activity In Vitro.

Diana D Wong1,2, Wendy J van Zuylen1,2, Stuart T Hamilton1,3, Mirjam Steingruber4, Eric Sonntag4, Manfred Marschall4, William D Rawlinson5,2,3,6.   

Abstract

Mutations in the cytomegalovirus UL97 kinase gene contribute to antiviral resistance. Mutations A594S and G598D from two clinical isolates were analyzed, and bacterial artificial chromosome (BAC)-engineered A594S recombinant cytomegalovirus exhibited a ganciclovir-resistant phenotype on plaque reduction. Viral replication was comparable to that of the wild type. Cell-based kinase activity and autophosphorylation of ectopically expressed proteins showed that mutants retained some kinase activity. This study showed that patient-derived cytomegalovirus with different ganciclovir sensitivities retained replication efficiency and exhibited some kinase activity in vitro.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  UL97; cytomegalovirus; drug resistance; ganciclovir; mutation; phosphorylation; protein kinase

Mesh：

Substances：

Year:  2019        PMID： 31262766      PMCID： PMC6709455          DOI： 10.1128/AAC.02425-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

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Authors:  G Halwachs-Baumann; M Wilders-Truschnig; G Enzinger; M Eibl; W Linkesch; H J Dornbusch; B I Santner; E Marth; H H Kessler
Journal:  J Clin Virol       Date:  2001-01       Impact factor: 3.168

2.  Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir.

Authors:  Sunwen Chou; Rachel H Waldemer; Anne E Senters; Kevin S Michels; George W Kemble; Richard C Miner; W Lawrence Drew
Journal:  J Infect Dis       Date:  2001-12-17       Impact factor: 5.226

3.  Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance.

Authors:  Sunwen Chou; Ronald J Ercolani; Gail Marousek; Terry L Bowlin
Journal:  Antimicrob Agents Chemother       Date:  2013-05-06       Impact factor: 5.191

4.  Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease.

Authors:  S Chou; G Marousek; S Guentzel; S E Follansbee; M E Poscher; J P Lalezari; R C Miner; W L Drew
Journal:  J Infect Dis       Date:  1997-09       Impact factor: 5.226

Review 5.  Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.

Authors:  William D Rawlinson; Suresh B Boppana; Karen B Fowler; David W Kimberlin; Tiziana Lazzarotto; Sophie Alain; Kate Daly; Sara Doutré; Laura Gibson; Michelle L Giles; Janelle Greenlee; Stuart T Hamilton; Gail J Harrison; Lisa Hui; Cheryl A Jones; Pamela Palasanthiran; Mark R Schleiss; Antonia W Shand; Wendy J van Zuylen
Journal:  Lancet Infect Dis       Date:  2017-03-11       Impact factor: 25.071

6.  Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation.

Authors:  Francisco M Marty; Per Ljungman; Roy F Chemaly; Johan Maertens; Sanjeet S Dadwal; Rafael F Duarte; Shariq Haider; Andrew J Ullmann; Yuta Katayama; Janice Brown; Kathleen M Mullane; Michael Boeckh; Emily A Blumberg; Hermann Einsele; David R Snydman; Yoshinobu Kanda; Mark J DiNubile; Valerie L Teal; Hong Wan; Yoshihiko Murata; Nicholas A Kartsonis; Randi Y Leavitt; Cyrus Badshah
Journal:  N Engl J Med       Date:  2017-12-06       Impact factor: 91.245

Review 7.  Cytomegalovirus and HIV: A Dangerous Pas de Deux.

Authors:  Sara Gianella; Scott Letendre
Journal:  J Infect Dis       Date:  2016-10-01       Impact factor: 5.226

8.  Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.

Authors:  Jeremy P Kamil; Adam J Hume; Igor Jurak; Karl Münger; Robert F Kalejta; Donald M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-15       Impact factor: 11.205

9.  The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors.

Authors:  C Hutterer; S Hamilton; M Steingruber; I Zeitträger; H Bahsi; N Thuma; Z Naing; Z Örfi; L Örfi; E Socher; H Sticht; W Rawlinson; S Chou; V J Haupt; M Marschall
Journal:  Antiviral Res       Date:  2016-08-08       Impact factor: 5.970

10.  Cytomegalovirus resistance to ganciclovir and clinical outcomes of patients with cytomegalovirus retinitis.

Authors:  Douglas A Jabs; Barbara K Martin; Michael S Forman; Larry Hubbard; J P Dunn; John H Kempen; Janet L Davis; David V Weinberg
Journal:  Am J Ophthalmol       Date:  2003-01       Impact factor: 5.258
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  1 in total

1.  Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H.

Authors:  Martin Schütz; Regina Müller; Eileen Socher; Christina Wangen; Florian Full; Emanuel Wyler; Diana Wong; Myriam Scherer; Thomas Stamminger; Sunwen Chou; William D Rawlinson; Stuart T Hamilton; Heinrich Sticht; Manfred Marschall
Journal:  Int J Mol Sci       Date:  2022-10-05       Impact factor: 6.208
  1 in total

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