Haibin Li1, Dianqin Sun2, Anxin Wang1, Huiying Pan2, Wei Feng1, Chee H Ng3, Gabor S Ungvari4, Lixin Tao1, Xia Li5, Wei Wang6, Yu-Tao Xiang7, Xiuhua Guo8. 1. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China. 2. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China. 3. Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. 4. University of Notre Dame Australia, Fremantle, Australia; Division of Psychiatry, Medical School, University of Western Australia, Perth, Australia. 5. Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia. 6. Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Australia. 7. Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address: xyutly@gmail.com. 8. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China. Electronic address: statguo@ccmu.edu.cn.
Abstract
OBJECTIVE: The association between serum vitamin D and risk of depression in older adults is controversial. We performed a dose-response meta-analysis of prospective cohort studies to examine the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and the risk of depression in older population. METHODS: Studies published before February 2018 in the PubMed, Cochrane Library, Web of Science, PsycINFO, and EMBASE databases were systematically searched. Prospective cohort studies that examined the association between serum 25(OH)D levels and the risk of depression in older adults were included. A random-effects model was used to calculate the pooled hazard ratio and the corresponding 95% confidence intervals. A nonlinear dose-response association was examined using restricted cubic spline functions. RESULTS: Six prospective studies covering 16,287 older adults with 1,157 cases of depression were included and analyzed. The pooled hazard ratio of depression for per 10-ng/mL increment in serum 25(OH)D was 0.88 (95% confidence intervals: 0.78-0.99, I2 = 79.0%, p <0.001 for heterogeneity). A linear dose-response association between serum 25(OH)D concentrations and incident depression was observed (p = 0.96 for nonlinearity). CONCLUSION: Serum 25(OH)D concentration is negatively associated with the risk of depression in older adults. This meta-analysis suggests that increasing 25(OH)D levels may be a useful approach to reduce the risk of depression in older adults and highlights the need for further large-scale clinical studies.
OBJECTIVE: The association between serum vitamin D and risk of depression in older adults is controversial. We performed a dose-response meta-analysis of prospective cohort studies to examine the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and the risk of depression in older population. METHODS: Studies published before February 2018 in the PubMed, Cochrane Library, Web of Science, PsycINFO, and EMBASE databases were systematically searched. Prospective cohort studies that examined the association between serum 25(OH)D levels and the risk of depression in older adults were included. A random-effects model was used to calculate the pooled hazard ratio and the corresponding 95% confidence intervals. A nonlinear dose-response association was examined using restricted cubic spline functions. RESULTS: Six prospective studies covering 16,287 older adults with 1,157 cases of depression were included and analyzed. The pooled hazard ratio of depression for per 10-ng/mL increment in serum 25(OH)D was 0.88 (95% confidence intervals: 0.78-0.99, I2 = 79.0%, p <0.001 for heterogeneity). A linear dose-response association between serum 25(OH)D concentrations and incident depression was observed (p = 0.96 for nonlinearity). CONCLUSION: Serum 25(OH)D concentration is negatively associated with the risk of depression in older adults. This meta-analysis suggests that increasing 25(OH)D levels may be a useful approach to reduce the risk of depression in older adults and highlights the need for further large-scale clinical studies.
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