| Literature DB >> 3126257 |
P Ralph1, I Nakoinz, D Rennick.
Abstract
Pretreatment of murine peritoneal exudate macrophages with 1-5 U/ml rIFN-gamma or rIL-2, or higher concentrations of IFN-alpha or IFN-beta greatly stimulated ADCC to Rl lymphoma targets. The assay was direct counting of viable target cells after 9 and 24 h using an E/T ratio of 5:1. 2d of pretreatment was optimal for enhancing ADCC. rIL-4 was inactive and IL-4-depleted Con A-induced spleen lymphokine retained its ADCC-stimulating activity. Antibody to IFN-gamma blocked the ADCC-promoting effect of the lymphokine, suggesting a major role for this factor.Entities:
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Year: 1988 PMID： 3126257 PMCID： PMC2188823 DOI： 10.1084/jem.167.2.712
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307