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Literature DB >> 31262533

Molecular Mechanism of HIV-1 Entry.

Abstract

HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3] attaches the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate infection. It interacts with the primary receptor CD4 and coreceptor (e.g., chemokine receptor CCR5 or CXCR4) to allow viral entry by triggering large structural rearrangements and unleashing the fusogenic potential of gp41 to induce membrane fusion. Recent advances in structural biology of HIV-1 Env and its complexes with the cellular receptors have revealed molecular details of HIV-1 entry and yielded new mechanistic insights. In this review, I summarize our latest understanding of the HIV-1 membrane fusion process and discuss possible pathways for productive viral entry.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: HIV-1; envelope glycoprotein; membrane fusion; viral entry

Year: 2019 PMID： 31262533 PMCID： PMC6744290 DOI： 10.1016/j.tim.2019.06.002

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

116 in total

1. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

Authors: T B Geijtenbeek; D S Kwon; R Torensma; S J van Vliet; G C van Duijnhoven; J Middel; I L Cornelissen; H S Nottet; V N KewalRamani; D R Littman; C G Figdor; Y van Kooyk
Journal: Cell Date: 2000-03-03 Impact factor: 41.582

2. Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120.

Authors: C Rizzuto; J Sodroski
Journal: AIDS Res Hum Retroviruses Date: 2000-05-20 Impact factor: 2.205

3. Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.

Authors: P D Kwong; R Wyatt; S Majeed; J Robinson; R W Sweet; J Sodroski; W A Hendrickson
Journal: Structure Date: 2000-12-15 Impact factor: 5.006

4. Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein.

Authors: T L Hoffman; C C LaBranche; W Zhang; G Canziani; J Robinson; I Chaiken; J A Hoxie; R W Doms
Journal: Proc Natl Acad Sci U S A Date: 1999-05-25 Impact factor: 11.205

Review 5. Structural basis for membrane fusion by enveloped viruses.

Authors: W Weissenhorn; A Dessen; L J Calder; S C Harrison; J J Skehel; D C Wiley
Journal: Mol Membr Biol Date: 1999 Jan-Mar Impact factor: 2.857

Review 6. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.

Authors: E A Berger; P M Murphy; J M Farber
Journal: Annu Rev Immunol Date: 1999 Impact factor: 28.527

7. Cooperative subunit interactions within the oligomeric envelope glycoprotein of HIV-1: functional complementation of specific defects in gp120 and gp41.

Authors: K Salzwedel; E A Berger
Journal: Proc Natl Acad Sci U S A Date: 2000-11-07 Impact factor: 11.205

8. The crystal structure of the SIV gp41 ectodomain at 1.47 A resolution.

Authors: Z N Yang; T C Mueser; J Kaufman; S J Stahl; P T Wingfield; C C Hyde
Journal: J Struct Biol Date: 1999-06-15 Impact factor: 2.867

9. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.

Authors: M Farzan; T Mirzabekov; P Kolchinsky; R Wyatt; M Cayabyab; N P Gerard; C Gerard; J Sodroski; H Choe
Journal: Cell Date: 1999-03-05 Impact factor: 41.582

10. Constitutive cell surface association between CD4 and CCR5.

Authors: X Xiao; L Wu; T S Stantchev; Y R Feng; S Ugolini; H Chen; Z Shen; J L Riley; C C Broder; Q J Sattentau; D S Dimitrov
Journal: Proc Natl Acad Sci U S A Date: 1999-06-22 Impact factor: 11.205

67 in total

1. Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding.

Authors: Tomoyuki Murakami; Nancy Carmona; Akira Ono
Journal: Proc Natl Acad Sci U S A Date: 2020-03-19 Impact factor: 11.205

Review 2. Lipid rafts and pathogens: the art of deception and exploitation.

Authors: Michael I Bukrinsky; Nigora Mukhamedova; Dmitri Sviridov
Journal: J Lipid Res Date: 2019-10-15 Impact factor: 5.922

3. Flow Cytometry Analysis of HIV-1 Env Conformations at the Surface of Infected Cells and Virions: Role of Nef, CD4, and SERINC5.

Authors: Isabelle Staropoli; Jérémy Dufloo; Olivier Schwartz; Nicoletta Casartelli; Anaïs Ducher; Pierre-Henri Commere; Anna Sartori-Rupp; Sophie Novault; Timothée Bruel; Valérie Lorin; Hugo Mouquet
Journal: J Virol Date: 2020-02-28 Impact factor: 5.103

10. Interactions of HIV gp41's membrane-proximal external region and transmembrane domain with phospholipid membranes from ³¹P NMR.

Authors: Madeleine Sutherland; Byungsu Kwon; Mei Hong
Journal: Biochim Biophys Acta Biomembr Date: 2021-08-02 Impact factor: 3.747