Literature DB >> 3126082

Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic beta-cells.

T Nilsson1, J Zwiller, A L Boynton, P O Berggren.   

Abstract

Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic beta-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+.

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Year:  1988        PMID： 3126082     DOI： 10.1016/0014-5793(88)80829-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

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5.  Heparin specifically inhibits the inositol 1,4,5-trisphosphate-induced Ca2+ release from skinned rat aortic smooth muscle cells in primary culture.

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Review 10.  Heparin: an intervenor in cell communication.

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  10 in total

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