Literature DB >> 3126076

Tolerance to relaxation in rat aorta: comparison of an S-nitrosothiol with nitroglycerin.

E A Kowaluk1, R Poliszczuk, H L Fung.   

Abstract

Tolerance and cross-tolerance to the relaxant effects of S-nitroso-N-acetylpenicillamine (SNAP) and nitroglycerin were examined in rat aortic rings. Nitroglycerin-tolerant rings remained fully responsive to SNAP and sodium nitroprusside. Thus, reduced metabolic activation of nitroglycerin, rather than impaired guanylate cyclase activity, appeared to be the operating mechanism for nitrate tolerance in this preparation. Under similar conditions, SNAP incubation induced less tolerance than nitroglycerin. S-nitrosothiols, therefore, appear to be less tolerance-producing than nitroglycerin.

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Year:  1987        PMID： 3126076     DOI： 10.1016/0014-2999(87)90392-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response.

Authors:  Parimala Nacharaju; Chaim Tuckman-Vernon; Keith E Maier; Jason Chouake; Adam Friedman; Pedro Cabrales; Joel M Friedman
Journal:  Nitric Oxide       Date:  2012-06-15       Impact factor: 4.427

2.  Voltage-gated calcium channel currents in human coronary myocytes. Regulation by cyclic GMP and nitric oxide.

Authors:  J F Quignard; J M Frapier; M C Harricane; B Albat; J Nargeot; S Richard
Journal:  J Clin Invest       Date:  1997-01-15       Impact factor: 14.808

3.  S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators.

Authors:  P J Henry; O H Drummer; J D Horowitz
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

4.  Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus.

Authors:  A J Barbier; R A Lefebvre
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

5.  Pharmacologic and pharmacokinetic profile of repifermin (KGF-2) in monkeys and comparative pharmacokinetics in humans.

Authors:  Cynthia Sung; Tom J Parry; Todd A Riccobene; Angela Mahoney; Viktor Roschke; James Murray; Mi Li Gu; Jeffrey K Glenn; Florence Caputo; Cindy Farman; Daniel J Odenheimer
Journal:  AAPS PharmSci       Date:  2002

6.  Chemical stabilization of a vasoactive S-nitrosothiol with cyclodextrins without loss of pharmacologic activity.

Authors:  J A Bauer; H L Fung
Journal:  Pharm Res       Date:  1991-10       Impact factor: 4.200

7.  Activation and inhibition of soluble guanylyl cyclase by S-nitrosocysteine: involvement of amino acid transport system L.

Authors:  Joseph A Riego; Katarzyna A Broniowska; Nicholas J Kettenhofen; Neil Hogg
Journal:  Free Radic Biol Med       Date:  2009-05-03       Impact factor: 7.376

Review 8.  The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles.

Authors:  B Mayer; M Beretta
Journal:  Br J Pharmacol       Date:  2008-06-23       Impact factor: 8.739
  8 in total

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