Literature DB >> 31259013

A Literature Based Discovery Visualization System with Hierarchical Clustering and Linking Set Associations.

Sam Henry1, Aliakbar Panahi1, D Shanaka Wijesinghe2, Bridget T McInnes1.   

Abstract

Literature Based discovery (LBD) seeks to find information implicit in text, but never explicitly stated. In this work, we develop a method of visually summarizing LBD output in an automatically generated tree structure. This structure promotes a comprehensive understanding of LBD output as a whole, and encourages the user to explore branches of the hierarchy they find most interesting or surprising. This novel visualization system requires the development and integration of automatic functional group discovery, set associations, and linking set associations. Specifically, we perform hierarchical clustering on the potential discoveries generated by an LBD system to create a tree of potential hypotheses. We weight the tree by developing set association measures, and extending them to linking set association measures. This weighted tree is displayed in an interactive visual environment, and validated by replicating the historic Raynaud's Disease - fish oil discovery.

Year:  2019        PMID: 31259013      PMCID: PMC6568119     

Source DB:  PubMed          Journal:  AMIA Jt Summits Transl Sci Proc


  5 in total

1.  Exploration of Shared Themes Between Food Security and Internet of Things Research Through Literature-Based Discovery.

Authors:  Cristian Mejia; Yuya Kajikawa
Journal:  Front Res Metr Anal       Date:  2021-05-13

2.  Indirect association and ranking hypotheses for literature based discovery.

Authors:  Sam Henry; Bridget T McInnes
Journal:  BMC Bioinformatics       Date:  2019-08-15       Impact factor: 3.169

3.  Adera2.0: A Drug Repurposing Workflow for Neuroimmunological Investigations Using Neural Networks.

Authors:  Marzena Lazarczyk; Kamila Duda; Michel Edwar Mickael; Onurhan Ak; Justyna Paszkiewicz; Agnieszka Kowalczyk; Jarosław Olav Horbańczuk; Mariusz Sacharczuk
Journal:  Molecules       Date:  2022-09-30       Impact factor: 4.927

4.  Semantic text mining in early drug discovery for type 2 diabetes.

Authors:  Lena K Hansson; Rasmus Borup Hansen; Sune Pletscher-Frankild; Rudolfs Berzins; Daniel Hvidberg Hansen; Dennis Madsen; Sten B Christensen; Malene Revsbech Christiansen; Ulrika Boulund; Xenia Asbæk Wolf; Sonny Kim Kjærulff; Martijn van de Bunt; Søren Tulin; Thomas Skøt Jensen; Rasmus Wernersson; Jan Nygaard Jensen
Journal:  PLoS One       Date:  2020-06-15       Impact factor: 3.240

5.  Using Literature Based Discovery to Gain Insights Into the Metabolomic Processes of Cardiac Arrest.

Authors:  Sam Henry; D Shanaka Wijesinghe; Aidan Myers; Bridget T McInnes
Journal:  Front Res Metr Anal       Date:  2021-06-25
  5 in total

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