Manisha Notay1, Suzana Saric-Bosanac2, Alexandra R Vaughn1, Simran Dhaliwal1, Megha Trivedi3, Paloma N Reiter4, Iryna Rybak1, Connie C Li5, Larry B Weiss5, Lauren Ambrogio5, Waqas Burney1, Raja K Sivamani1,6,7. 1. Department of Dermatology, University of California, Davis, Sacramento, California, USA. 2. School of Medicine, University of California, Davis, Sacramento, California, USA. 3. University of Michigan Medical School, Ann Arbor, Michigan, USA. 4. College of Osteopathic Medicine, Nova Southeastern University, Davie, Florida, USA. 5. AOBiome LLC, Cambridge, Massachusetts, USA. 6. California State University, Sacramento, California, USA. 7. Pacific Skin Institute, Sacramento, California, USA.
Abstract
BACKGROUND: Both topical and oral probiotics are becoming widely used. There is increasing interest in the cosmetic potential in topical probiotics. Nitrosomonas eutropha is an ammonia-oxidizing bacteria. AIM: The purpose of this study was to assess whether there is any improvement in facial wrinkles with the use of Nitrosomonas eutropha, a topical probiotic. METHODS: In this prospective study, high-resolution photographs were obtained in twenty-nine participants at baseline and after using topical Nitrosomonas eutropha for seven days. RESULTS: There was a significant difference in wrinkle depth and severity in the high concentration probiotic group. There was also a statistically significant improvement in pigmentation of the forehead and glabella in the higher concentration group. CONCLUSIONS: Nitrosomonas eutropha may have aesthetic benefits in terms of reducing the appearance of wrinkles. Larger studies with longer treatment and follow-up periods are required.
BACKGROUND: Both topical and oral probiotics are becoming widely used. There is increasing interest in the cosmetic potential in topical probiotics. Nitrosomonas eutropha is an ammonia-oxidizing bacteria. AIM: The purpose of this study was to assess whether there is any improvement in facial wrinkles with the use of Nitrosomonas eutropha, a topical probiotic. METHODS: In this prospective study, high-resolution photographs were obtained in twenty-nine participants at baseline and after using topical Nitrosomonas eutropha for seven days. RESULTS: There was a significant difference in wrinkle depth and severity in the high concentration probiotic group. There was also a statistically significant improvement in pigmentation of the forehead and glabella in the higher concentration group. CONCLUSIONS:Nitrosomonas eutropha may have aesthetic benefits in terms of reducing the appearance of wrinkles. Larger studies with longer treatment and follow-up periods are required.