Literature DB >> 31257385

Visible-range hemi-indigo photoswitch: ON-OFF fluorescent binder for HIV-1 RNA.

Daria V Berdnikova1.   

Abstract

A proof-of-principle for the application of hemi-indigo derivatives as RNA binders with photocontrollable fluorescence is presented. The photoswitch binds to the human immunodeficiency virus type 1 (HIV-1) RNA with a significant light-up effect. The fluorescence of the RNA-bound ligand can be reversibly switched ON and OFF by light without destroying the ligand-RNA associates.

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Year:  2019        PMID： 31257385     DOI： 10.1039/c9cc04270a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  Molecular photoswitches in aqueous environments.

Authors:  Jana Volarić; Wiktor Szymanski; Nadja A Simeth; Ben L Feringa
Journal:  Chem Soc Rev       Date:  2021-11-15       Impact factor: 54.564

2.  Novel base-initiated cascade reactions of hemiindigos to produce dipolar γ-carbolines and indole-fused pentacycles.

Authors:  V S Velezheva; O L Babii; A A Khodak; E A Alekseeva; Yu V Nelyubina; I A Godovikov; A S Peregudov; K B Majorov; B V Nikonenko
Journal:  RSC Adv       Date:  2019-12-13       Impact factor: 4.036

3.  Design, synthesis and investigation of water-soluble hemi-indigo photoswitches for bioapplications.

Authors:  Daria V Berdnikova
Journal:  Beilstein J Org Chem       Date:  2019-11-22       Impact factor: 2.883

Review 4.  Role and Perspective of Molecular Simulation-Based Investigation of RNA-Ligand Interaction: From Small Molecules and Peptides to Photoswitchable RNA Binding.

Authors:  Daria V Berdnikova; Paolo Carloni; Sybille Krauß; Giulia Rossetti
Journal:  Molecules       Date:  2021-06-03       Impact factor: 4.411

5.  Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer.

Authors:  Nadja A Simeth; Shotaro Kobayashi; Piermichele Kobauri; Stefano Crespi; Wiktor Szymanski; Kazuhiko Nakatani; Chikara Dohno; Ben L Feringa
Journal:  Chem Sci       Date:  2021-05-27       Impact factor: 9.825
  5 in total

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