Keita Sakurai1, Aya M Tokumaru2, Toshimasa Ikeda3, Satoru Morimoto4, Shohei Inui5,6, Kaoru Sumida5, Hiroshi Oba5, Motoo Nakagawa7, Noriyuki Matsukawa3, Yoshio Hashizume8. 1. Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. ksak666@yahoo.co.jp. 2. Department of Diagnostic Radiology, Tokyo Metropolitan Medical center of Gerontology, Tokyo, Japan. 3. Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. 4. Department of Physiology, School of Medicine, Keio University, Tokyo, Japan. 5. Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. 6. Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 7. Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. 8. Fukushimura Hospital, Choju Medical Institute, Tokyo, Japan.
Abstract
PURPOSE: The purpose of this study is to clarify the characteristic structural magnetic resonance imaging (MRI) findings in demented patients with pathologically confirmed argyrophilic grain disease (AGD). METHODS: Nine pathologically confirmed AGD patients with cerebral three-dimensional T1-weighted MRI were evaluated in this study. In addition to visual rating scales of atrophic and asymmetric changes in the limbic and temporal lobes, voxel-based morphometry (VBM) was performed to assess group difference between pathologically confirmed AGD and Alzheimer's disease (AD) patients. RESULTS: On visual analyses of AGD patients, the medial temporal, anterior temporal, and posterior temporal atrophy scores were 3.3 ± 0.7, 1.7 ± 0.5, and 1.0 ± 0.7, respectively. Asymmetric scores of the hippocampus and parahippocampal gyrus, amygdala and ambient gyrus, anterior temporal, and posterior temporal lobes were rated as 1.1 ± 0.7, 1.6 ± 0.5, 1.3 ± 0.8, and 0.4 ± 0.7, respectively. In spite of no statistical differences in atrophic scores, AGD patients showed the higher score and proportion of anterior temporal asymmetric score than AD (p = 0.03 and 0.02). Compared with controls, VBM analysis revealed left dominant asymmetric atrophy predominantly in the limbic and anterior temporal lobe in AGD patients. By contrast, there was no significant gray matter reduction between AGD and AD patients. CONCLUSIONS: Asymmetric atrophy relatively localized to the anterior temporal and limbic lobes including the amygdala and ambient gyrus is a characteristic MRI finding of AGD. For the precise antemortem diagnosis, especially to differentiation from AD, it is important to pay attention to this asymmetric change.
PURPOSE: The purpose of this study is to clarify the characteristic structural magnetic resonance imaging (MRI) findings in demented patients with pathologically confirmed argyrophilic grain disease (AGD). METHODS: Nine pathologically confirmed AGD patients with cerebral three-dimensional T1-weighted MRI were evaluated in this study. In addition to visual rating scales of atrophic and asymmetric changes in the limbic and temporal lobes, voxel-based morphometry (VBM) was performed to assess group difference between pathologically confirmed AGD and Alzheimer's disease (AD) patients. RESULTS: On visual analyses of AGD patients, the medial temporal, anterior temporal, and posterior temporal atrophy scores were 3.3 ± 0.7, 1.7 ± 0.5, and 1.0 ± 0.7, respectively. Asymmetric scores of the hippocampus and parahippocampal gyrus, amygdala and ambient gyrus, anterior temporal, and posterior temporal lobes were rated as 1.1 ± 0.7, 1.6 ± 0.5, 1.3 ± 0.8, and 0.4 ± 0.7, respectively. In spite of no statistical differences in atrophic scores, AGD patients showed the higher score and proportion of anterior temporal asymmetric score than AD (p = 0.03 and 0.02). Compared with controls, VBM analysis revealed left dominant asymmetric atrophy predominantly in the limbic and anterior temporal lobe in AGD patients. By contrast, there was no significant gray matter reduction between AGD and ADpatients. CONCLUSIONS: Asymmetric atrophy relatively localized to the anterior temporal and limbic lobes including the amygdala and ambient gyrus is a characteristic MRI finding of AGD. For the precise antemortem diagnosis, especially to differentiation from AD, it is important to pay attention to this asymmetric change.
Authors: S S Mirra; A Heyman; D McKeel; S M Sumi; B J Crain; L M Brownlee; F S Vogel; J P Hughes; G van Belle; L Berg Journal: Neurology Date: 1991-04 Impact factor: 9.910
Authors: J L Whitwell; C R Jack; B F Boeve; J E Parisi; J E Ahlskog; D A Drubach; M L Senjem; D S Knopman; R C Petersen; D W Dickson; K A Josephs Journal: Neurology Date: 2010-11-23 Impact factor: 9.910
Authors: Keith A Josephs; Jennifer L Whitwell; Joseph E Parisi; David S Knopman; Bradley F Boeve; Yonas E Geda; Clifford R Jack; Ronald C Petersen; Dennis W Dickson Journal: Neurobiol Aging Date: 2006-12-26 Impact factor: 4.673
Authors: I Litvan; J J Hauw; J J Bartko; P L Lantos; S E Daniel; D S Horoupian; A McKee; D Dickson; C Bancher; M Tabaton; K Jellinger; D W Anderson Journal: J Neuropathol Exp Neurol Date: 1996-01 Impact factor: 3.685