| Literature DB >> 31256143 |
Nobutaka Sakae1, Michael G Heckman2, Emily R Vargas2, Minerva M Carrasquillo1, Melissa E Murray1, Koji Kasanuki1, Nilufer Ertekin-Taner1,3, Steven G Younkin1, Dennis W Dickson1.
Abstract
A number of Alzheimer's disease (AD) susceptibility loci are expressed abundantly in microglia. We examined associations between AD risk variants in genes that are highly expressed in microglia and neuropathological outcomes, including cerebral amyloid angiopathy (CAA) and microglial activation, in 93 AD patients. We observed significant associations of CAA pathology with APOEɛ4 and PTK2B rs28834970. Nominally significant associations with measures of microglial activation in white matter were observed for variants in PTK2B, PICALM, and CR1. Our findings suggest that several AD risk variants may also function as disease modifiers through amyloid-β metabolism and white matter microglial activity.Entities:
Keywords: Alzheimer’s disease; genome-wide association study; microglia; neuropathology; risk variant
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Year: 2019 PMID： 31256143 DOI： 10.3233/JAD-190451
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472