Ilse Lamers1, Joke Raats2, Jan Spaas2, Michaël Meuleman2, Lore Kerkhofs3, Sofie Schouteden3, Peter Feys2. 1. REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Martelarenlaan 42, Hasselt 3500, Belgium; Rehabilitation and MS center, Boemerangstraat 2, Overpelt 3900, Belgium. Electronic address: ilse.lamers@uhasselt.be. 2. REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Martelarenlaan 42, Hasselt 3500, Belgium. 3. Rehabilitation and MS center, Boemerangstraat 2, Overpelt 3900, Belgium.
Abstract
BACKGROUND:Task-oriented training promotes functional recovery in Multiple Sclerosis (MS). Know-how to determine an individualized training intensity and intensity-dependent effects are, however, unknown. The objective of the study was to investigate the feasibility and the clinical effects of a task-oriented upper limb training program at different individualized training intensities with conventional occupational therapy. METHODS:People with MS (n = 20, EDSS range 4-8) were divided into three groups, receiving task-oriented training at 100% (n = 7) or 50% (n = 8) of their individual maximal number of repetitions, or conventional occupational therapy (n = 5). Effects were evaluated using different upper limb capacity and perceived performance measures on activity level, and measures on body functions and structures level. RESULTS: Mixed model analyses revealed significant improvements (p < 0.05) over time on the Box and block test (BBT), Action Research Arm Test and the Manual Ability Measure-36. Significant interaction effects (group*time) in favor of the task-oriented group training at the highest intensity were found for BBT and static fatigue index during a maximal sustained handgrip strength test. CONCLUSION: All participants were able to perform the task-oriented training at their individualized intensity without any adverse effects. Several improvements over time were found for all intervention groups, however the results suggest a superiority of task-oriented training at 100%. CLINICAL TRIAL REGISTRATION NUMBER ON CLINICALTRIALS.GOV: = NCT02688231.
RCT Entities:
BACKGROUND: Task-oriented training promotes functional recovery in Multiple Sclerosis (MS). Know-how to determine an individualized training intensity and intensity-dependent effects are, however, unknown. The objective of the study was to investigate the feasibility and the clinical effects of a task-oriented upper limb training program at different individualized training intensities with conventional occupational therapy. METHODS:People with MS (n = 20, EDSS range 4-8) were divided into three groups, receiving task-oriented training at 100% (n = 7) or 50% (n = 8) of their individual maximal number of repetitions, or conventional occupational therapy (n = 5). Effects were evaluated using different upper limb capacity and perceived performance measures on activity level, and measures on body functions and structures level. RESULTS: Mixed model analyses revealed significant improvements (p < 0.05) over time on the Box and block test (BBT), Action Research Arm Test and the Manual Ability Measure-36. Significant interaction effects (group*time) in favor of the task-oriented group training at the highest intensity were found for BBT and static fatigue index during a maximal sustained handgrip strength test. CONCLUSION: All participants were able to perform the task-oriented training at their individualized intensity without any adverse effects. Several improvements over time were found for all intervention groups, however the results suggest a superiority of task-oriented training at 100%. CLINICAL TRIAL REGISTRATION NUMBER ON CLINICALTRIALS.GOV: = NCT02688231.
Authors: Christoph M Kanzler; Mike D Rinderknecht; Anne Schwarz; Ilse Lamers; Cynthia Gagnon; Jeremia P O Held; Peter Feys; Andreas R Luft; Roger Gassert; Olivier Lambercy Journal: NPJ Digit Med Date: 2020-05-29
Authors: Luis De-Bernardi-Ojuel; Laura Torres-Collado; Manuela García-de-la-Hera Journal: Int J Environ Res Public Health Date: 2021-02-03 Impact factor: 3.390
Authors: Christoph M Kanzler; Ilse Lamers; Peter Feys; Roger Gassert; Olivier Lambercy Journal: Med Biol Eng Comput Date: 2021-11-25 Impact factor: 2.602