Oscar L Lopez1, Yuefang Chang2, Diane G Ives3, Beth E Snitz4, Annette L Fitzpatrick5, Michelle C Carlson6, Stephen R Rapp7, Jeffrey D Williamson8, Russell P Tracy9, Steven T DeKosky10, Lewis H Kuller3. 1. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: lopezol@upmc.edu. 2. Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 3. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 4. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. 5. Department of Family Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA. 6. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 7. Department of Psychiatry and Behavioral Medicine, Wake Forest University, Winston-Salem, NC, USA. 8. Department of Medicine and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University, Winston-Salem, NC, USA. 9. Department of Pathology, University of Vermont, Colchester, VT, USA; Department of Biochemistry, University of Vermont, Colchester, VT, USA. 10. Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Abstract
INTRODUCTION: Both high or low plasma amyloid levels have been associated with risk of dementia in nondemented subjects. METHODS: We examined baseline plasma β-amyloid (Aβ) levels in relationship to incident dementia during a period of 8.5 years in 2840 subjects age >75 years; 2381 were cognitively normal (CN) and 450 mild cognitive impairment. RESULTS: Increased plasma Aβ1-40 and Aβ1-42 levels were associated with gender (women), age, low education, creatinine levels, history of stroke, and hypertension. CN participants who developed dementia had lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio compared with those who did not. Aβ levels did not predict dementia in mild cognitive impairment participants. DISCUSSION: There was an inverse association between Aβ1-42 and Aβ1-42/Aβ1-40 ratio to risk of dementia in CN participants. Cerebral and cardiovascular disease and renal function are important determinants of increased Aβ levels and must be considered in evaluations of relationship of plasma Aβ and subsequent risk of dementia.
INTRODUCTION: Both high or low plasma amyloid levels have been associated with risk of dementia in nondemented subjects. METHODS: We examined baseline plasma β-amyloid (Aβ) levels in relationship to incident dementia during a period of 8.5 years in 2840 subjects age >75 years; 2381 were cognitively normal (CN) and 450 mild cognitive impairment. RESULTS: Increased plasma Aβ1-40 and Aβ1-42 levels were associated with gender (women), age, low education, creatinine levels, history of stroke, and hypertension. CN participants who developed dementia had lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio compared with those who did not. Aβ levels did not predict dementia in mild cognitive impairmentparticipants. DISCUSSION: There was an inverse association between Aβ1-42 and Aβ1-42/Aβ1-40 ratio to risk of dementia in CN participants. Cerebral and cardiovascular disease and renal function are important determinants of increased Aβ levels and must be considered in evaluations of relationship of plasma Aβ and subsequent risk of dementia.
Authors: Nicholas M Pajewski; Fanny M Elahi; Manjula Kurella Tamura; Jason D Hinman; Ilya M Nasrallah; Joachim H Ix; Lindsay M Miller; Lenore J Launer; Clinton B Wright; Mark A Supiano; Alan J Lerner; Tiffany L Sudduth; Anthony A Killeen; Alfred K Cheung; David M Reboussin; Donna M Wilcock; Jeff D Williamson Journal: Alzheimers Dement Date: 2021-11-17 Impact factor: 16.655
Authors: Oscar L Lopez; William E Klunk; Chester A Mathis; Beth E Snitz; Yuefang Chang; Russell P Tracy; Lewis H Kuller Journal: Brain Commun Date: 2019-11-27
Authors: Sandra Maria Barbalho; Rosa Direito; Lucas Fornari Laurindo; Ledyane Taynara Marton; Elen Landgraf Guiguer; Ricardo de Alvares Goulart; Ricardo José Tofano; Antonely C A Carvalho; Uri Adrian Prync Flato; Viviane Alessandra Capelluppi Tofano; Cláudia Rucco Penteado Detregiachi; Patrícia C Santos Bueno; Raul S J Girio; Adriano Cressoni Araújo Journal: Antioxidants (Basel) Date: 2022-03-09