| Literature DB >> 31255386 |
Melissa Liebowitz1, Anup Katheria2, Jason Sauberan2, Jaideep Singh3, Kelly Nelson3, Denise C Hassinger4, Susan W Aucott5, Joseph Kaempf6, Amy Kimball7, Erika Fernandez7, William A Carey8, Jorge Perez9, Arturo Serize9, Andrea Wickremasinghe10, Lawrence Dong10, Matthew Derrick11, Ilene Sue Wolf11, Anne Marie Heuchan12, Meera Sankar13, Ali Bulbul14, Ronald I Clyman15.
Abstract
The PDA: TO LEave it alone or Respond And Treat Early trial compared the effects of 2 strategies for treatment of patent ductus arteriosus (PDA) in infants <280/7 weeks of gestation; however 137 potentially eligible infants were not recruited and received treatment of their PDA outside the PDA-TOLERATE trial due to "lack-of-physician-equipoise" (LPE). Despite being less mature and needing more respiratory support, infants with LPE had lower rates of mortality than enrolled infants. Infants with LPE treated before day 6 had lower rates of late respiratory morbidity than infants with LPE treated ≥day 6. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01958320.Entities:
Keywords: bronchopulmonary dysplasia; patent ductus arteriosus; premature birth
Mesh：
Year: 2019 PMID： 31255386 PMCID： PMC6765426 DOI： 10.1016/j.jpeds.2019.05.049
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406