Min Sun Jeon1, Young Mi Jeong1, Jeong Yee2, Eunsook Lee3, Kwang-Il Kim4, Byung Koo Lee2, Sandy Jeong Rhie2, Jee Eun Chung5, Hye Sun Gwak6. 1. College of Pharmacy & Division of Life Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, South Korea; Department of Pharmacy, Seoul National University Bundang Hospital, Seongnam, 13620, South Korea. 2. College of Pharmacy & Division of Life Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, South Korea. 3. Department of Pharmacy, Seoul National University Bundang Hospital, Seongnam, 13620, South Korea. 4. Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, South Korea. 5. College of Pharmacy, Hanyang University, Ansan, 15588, South Korea. Electronic address: jechung@hanyang.ac.kr. 6. College of Pharmacy & Division of Life Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, South Korea. Electronic address: hsgwak@ewha.ac.kr.
Abstract
BACKGROUND: This study aimed to determine whether pre-operative medication use is associated with unplanned 30-day readmission in elderly people undergoing cancer surgery. METHODS: Patients aged 65 years or older who were scheduled for cancer surgery and presented for comprehensive geriatric assessment were included. Comparisons of variables between patients with readmission and those without readmission were performed by univariate and multivariate analyses. RESULTS: A total of 473 patients were included. Multivariate analysis showed that pre-operative discontinuation-requiring medications (PDRMs) and gastrointestinal/hepato-pancreato-biliary (GI/HPB) cancer were significant factors for 30-day readmission. PDRM increased the risk of readmission by about 2.2-fold. Attributable risk of PDRM to readmission was around 55%. The adjusted odds ratio and attributable risk for GI/HPB surgery was 3.4 (95% CI 1.0-11.5) and 70.8%, respectively. CONCLUSIONS: Medication use has an impact on unplanned 30-day readmission in geriatric oncology patients, further highlighting the importance of medication optimization for elderly patients with cancer surgery.
BACKGROUND: This study aimed to determine whether pre-operative medication use is associated with unplanned 30-day readmission in elderly people undergoing cancer surgery. METHODS:Patients aged 65 years or older who were scheduled for cancer surgery and presented for comprehensive geriatric assessment were included. Comparisons of variables between patients with readmission and those without readmission were performed by univariate and multivariate analyses. RESULTS: A total of 473 patients were included. Multivariate analysis showed that pre-operative discontinuation-requiring medications (PDRMs) and gastrointestinal/hepato-pancreato-biliary (GI/HPB) cancer were significant factors for 30-day readmission. PDRM increased the risk of readmission by about 2.2-fold. Attributable risk of PDRM to readmission was around 55%. The adjusted odds ratio and attributable risk for GI/HPB surgery was 3.4 (95% CI 1.0-11.5) and 70.8%, respectively. CONCLUSIONS: Medication use has an impact on unplanned 30-day readmission in geriatric oncology patients, further highlighting the importance of medication optimization for elderly patients with cancer surgery.
Authors: Deniz Can Guven; Furkan Ceylan; Ibrahim Yahya Cakir; Engin Cesmeci; Basak Sayinalp; Berkay Yesilyurt; Gurkan Guner; Hasan Cagri Yildirim; Oktay Halit Aktepe; Zafer Arik; Alev Turker; Omer Dizdar Journal: Support Care Cancer Date: 2021-01-06 Impact factor: 3.603