| Literature DB >> 31253059 |
Ze Li1, Mingli Wu1, Haidong Zhao1, Lujie Fan1, Yu Zhang1, Tingting Yuan1, Shuai He1, Pengfei Wang2, Yunhai Zhang3, Xiuzhu Sun1, Shuhui Wang1.
Abstract
Pleomorphic adenoma gene 1 (PLAG1) encodes a developmentally regulated zinc finger protein, locating in growth-related QTNs. The mRNA expression of this gene was investigated in different tissues and from two different developmental periods, whilst to explore the functions of PLAG1 in growth traits of cattle. The results showed that PLAG1 was expressed in all examined tissues. However, PLAG1 expression levels in all examined tissues were significantly different between the 5-month fetus and 36-month adult cattle. Our juvenile results indicated PLAG1 is primarily expressed in embryonic tissues of Chinese cattle. Furthermore, two variations were identified. Association analysis revealed that the two variations were associated with growth traits (p < 0.05 or p < 0.01). These new findings provide a comprehensive overview of the critical roles of PLAG1 in growth traits modulation and can be highlighted as candidate molecular markers in cattle breeding.Entities:
Keywords: Cattle; association analysis; genetic variants; growth traits; mRNA expression
Year: 2019 PMID： 31253059 DOI： 10.1080/10495398.2019.1632207
Source DB: PubMed Journal: Anim Biotechnol ISSN： 1049-5398 Impact factor: 2.282