Peak oxygen uptake, six-minute walk distance, six-meter walk speed, and pulse pressure as predictors of seven year all-cause and cardiovascular mortality in community-living older adults.

Cardiorespiratory fitness and physical performance measures predict mortality. It is uncertain whether pulse pressure (PP), a measure that is routinely available in healthcare settings, may also predict mortality with a comparable degree of accuracy. In a study consisting of older adults (709 men and 467 women) living in the community, we examined the relationship between PP, peak oxygen uptake (VO2 peak), 6-minute walk distance (6MWD) and 6-meter walking speed (6MWS) and seven year all-cause and cardiovascular mortality. Receiver operator characteristic (ROC) curve was used to compare predictive performance. In the prediction of all-cause mortality, in men, 6MWD, 6MWS and PP all have comparable area under curve (AUC) values compared with VO2 peak: 0.736, 0.723, 0.736 and 0.734 respectively. Similar results were observed for women, although all the AUC values were slightly lower (corresponding values were 0.723, 0.713, 0.702 and 0.747 respectively). For cardiovascular mortality, the findings are similar although in men all AUC values were higher. We conclude that PP predicts 7 year all-cause and cardiovascular mortality in older adults with an accuracy similar to VO2 peak, 6MWD and 6MWS, although the association is less strong in women.