| Literature DB >> 31251124 |
Florian Oehme1, Stefan Krahl1, Balazs Gyorffy2,3, Benjamin Muessle1, Venkatesh Rao1, Helena Greif1, Nicole Ziegler1,4, Kuailu Lin1, May-Linn Thepkaysone1, Heike Polster1, Torsten Tonn5, Martin Schneider6, Juergen Weitz1, Franziska Baenke1,4, Christoph Kahlert1.
Abstract
Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69-11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time.Entities:
Keywords: Exosomes; colorectal cancer; diagnosis; liquid biopsy; long non-coding RNA
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Year: 2019 PMID： 31251124 PMCID： PMC6779381 DOI： 10.1080/15476286.2019.1637697
Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652