Maged Hassan1,2,3, Tamsin Cargill4, Elinor Harriss5, Rachelle Asciak4,2, Rachel M Mercer4,2, Eihab O Bedawi4,2, David J McCracken4,2, Ioannis Psallidas4,2, John P Corcoran6, Najib M Rahman4,2,7. 1. Oxford Pleural Unit, Oxford University Hospitals, Oxford, UK magedhmf@gmail.com. 2. Oxford Respiratory Trial Unit, University of Oxford, Oxford, UK. 3. Chest Diseases Dept, Alexandria Faculty of Medicine, Alexandria, Egypt. 4. Oxford Pleural Unit, Oxford University Hospitals, Oxford, UK. 5. Bodleian Healthcare Libraries, University of Oxford, Oxford, UK. 6. Interventional Pulmonology Service, Dept of Respiratory Medicine, University Hospitals Plymouth NHS Trust, Plymouth, UK. 7. Oxford NIHR Biomedical Research Centre, Oxford, UK.
Abstract
BACKGROUND AND OBJECTIVES: Pleural infection is a major cause of morbidity and mortality among adults. Identification of the offending organism is key to appropriate antimicrobial therapy. It is not known whether the microbiological pattern of pleural infection is variable temporally or geographically. This systematic review aimed to investigate available literature to understand the worldwide pattern of microbiology and the factors that might affect such pattern. DATA SOURCES AND ELIGIBILITY CRITERIA: Ovid MEDLINE and Embase were searched between 2000 and 2018 for publications that reported on the microbiology of pleural infection in adults. Both observational and interventional studies were included. Studies were excluded if the main focus of the report was paediatric population, tuberculous empyema or post-operative empyema. STUDY APPRAISAL AND SYNTHESIS METHODS: Studies of ≥20 patients with clear reporting of microbial isolates were included. The numbers of isolates of each specific organism/group were collated from the included studies. Besides the overall presentation of data, subgroup analyses by geographical distribution, infection setting (community versus hospital) and time of the report were performed. RESULTS: From 20 980 reports returned by the initial search, 75 articles reporting on 10 241 patients were included in the data synthesis. The most common organism reported worldwide was Staphylococcus aureus. Geographically, pneumococci and viridans streptococci were the most commonly reported isolates from tropical and temperate regions, respectively. The microbiological pattern was considerably different between community- and hospital-acquired infections, where more Gram-negative and drug-resistant isolates were reported in the hospital-acquired infections. The main limitations of this systematic review were the heterogeneity in the method of reporting of certain bacteria and the predominance of reports from Europe and South East Asia. CONCLUSIONS: In pleural infection, the geographical location and the setting of infection have considerable bearing on the expected causative organisms. This should be reflected in the choice of empirical antimicrobial treatment.
BACKGROUND AND OBJECTIVES: Pleural infection is a major cause of morbidity and mortality among adults. Identification of the offending organism is key to appropriate antimicrobial therapy. It is not known whether the microbiological pattern of pleural infection is variable temporally or geographically. This systematic review aimed to investigate available literature to understand the worldwide pattern of microbiology and the factors that might affect such pattern. DATA SOURCES AND ELIGIBILITY CRITERIA: Ovid MEDLINE and Embase were searched between 2000 and 2018 for publications that reported on the microbiology of pleural infection in adults. Both observational and interventional studies were included. Studies were excluded if the main focus of the report was paediatric population, tuberculous empyema or post-operative empyema. STUDY APPRAISAL AND SYNTHESIS METHODS: Studies of ≥20 patients with clear reporting of microbial isolates were included. The numbers of isolates of each specific organism/group were collated from the included studies. Besides the overall presentation of data, subgroup analyses by geographical distribution, infection setting (community versus hospital) and time of the report were performed. RESULTS: From 20 980 reports returned by the initial search, 75 articles reporting on 10 241 patients were included in the data synthesis. The most common organism reported worldwide was Staphylococcus aureus. Geographically, pneumococci and viridans streptococci were the most commonly reported isolates from tropical and temperate regions, respectively. The microbiological pattern was considerably different between community- and hospital-acquired infections, where more Gram-negative and drug-resistant isolates were reported in the hospital-acquired infections. The main limitations of this systematic review were the heterogeneity in the method of reporting of certain bacteria and the predominance of reports from Europe and South East Asia. CONCLUSIONS: In pleural infection, the geographical location and the setting of infection have considerable bearing on the expected causative organisms. This should be reflected in the choice of empirical antimicrobial treatment.
Authors: Tamsin N Cargill; Maged Hassan; John P Corcoran; Elinor Harriss; Rachelle Asciak; Rachel M Mercer; David J McCracken; Eihab O Bedawi; Najib M Rahman Journal: Eur Respir J Date: 2019-10-01 Impact factor: 16.671
Authors: Thomas Maitre; Vichita Ok; Ruxandra Calin; Ludovic Lassel; Ana Canestri; Michel Denis; Mohammed Hamidi; Sebastian Tavolaro; Charlotte Verdet; Antoine Parrot; Jacques Cadranel; Gilles Pialoux Journal: Ther Adv Respir Dis Date: 2021 Jan-Dec Impact factor: 4.031
Authors: José M Porcel; Lucia Ferreiro; Laura Rumi; Esther Espino-Paisán; Carmen Civit; Marina Pardina; Juan Antonio Schoenenberger-Arnaiz; Luis Valdés; Silvia Bielsa Journal: Pleura Peritoneum Date: 2020-02-26