Literature DB >> 3124763

Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) Moench.

D L Siehl1, E E Conn.   

Abstract

Arogenate dehydratase was purified sixfold from an extract of etiolated seedlings of Sorghum bicolor. Prephenate dehydratase was not detected. The arogenate dehydratase activity displayed hyperbolic substrate kinetics with a KM for arogenate of 0.32 mM. Activity was inhibited competitively by phenylalanine and was stimulated by tyrosine. The low KI for phenylalanine (24 microM) and KA for tyrosine (2.5 microM) indicated a high affinity of the enzyme for these effectors. These results establish the routing of metabolites in phenylalanine biosynthesis in sorghum as proceeding via arogenate rather than phenylpyruvate.

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Year:  1988        PMID： 3124763     DOI： 10.1016/0003-9861(88)90513-9

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  13 in total

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Journal:  Arabidopsis Book       Date:  2010-05-17

3.  Arogenate dehydratase isoenzymes profoundly and differentially modulate carbon flux into lignins.

Authors:  Oliver R A Corea; Chanyoung Ki; Claudia L Cardenas; Sung-Jin Kim; Sarah E Brewer; Ann M Patten; Laurence B Davin; Norman G Lewis
Journal:  J Biol Chem       Date:  2012-02-06       Impact factor: 5.157

4.  RNAi suppression of Arogenate Dehydratase1 reveals that phenylalanine is synthesized predominantly via the arogenate pathway in petunia petals.

Authors:  Hiroshi Maeda; Ajit K Shasany; Jennifer Schnepp; Irina Orlova; Goro Taguchi; Bruce R Cooper; David Rhodes; Eran Pichersky; Natalia Dudareva
Journal:  Plant Cell       Date:  2010-03-09       Impact factor: 11.277

Review 5.  Harnessing evolutionary diversification of primary metabolism for plant synthetic biology.

Authors:  Hiroshi A Maeda
Journal:  J Biol Chem       Date:  2019-09-26       Impact factor: 5.157

6.  Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism.

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Journal:  Plant Physiol       Date:  2018-03-09       Impact factor: 8.340

7.  Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts.

Authors:  Anne Pribat; Alexandre Noiriel; Alison M Morse; John M Davis; Romain Fouquet; Karen Loizeau; Stéphane Ravanel; Wolfgang Frank; Richard Haas; Ralf Reski; Mohamed Bedair; Lloyd W Sumner; Andrew D Hanson
Journal:  Plant Cell       Date:  2010-10-19       Impact factor: 11.277

8.  Mutation of a rice gene encoding a phenylalanine biosynthetic enzyme results in accumulation of phenylalanine and tryptophan.

Authors:  Tetsuya Yamada; Fumio Matsuda; Koji Kasai; Shuichi Fukuoka; Keisuke Kitamura; Yuzuru Tozawa; Hisashi Miyagawa; Kyo Wakasa
Journal:  Plant Cell       Date:  2008-05-16       Impact factor: 11.277

9.  Tyrosine and phenylalanine are synthesized within the plastids in Arabidopsis.

Authors:  Pascal Rippert; Juliette Puyaubert; Delphine Grisollet; Laure Derrier; Michel Matringe
Journal:  Plant Physiol       Date:  2009-01-09       Impact factor: 8.340

10.  Three different classes of aminotransferases evolved prephenate aminotransferase functionality in arogenate-competent microorganisms.

Authors:  Matthieu Graindorge; Cécile Giustini; Alexandra Kraut; Lucas Moyet; Gilles Curien; Michel Matringe
Journal:  J Biol Chem       Date:  2013-12-03       Impact factor: 5.157
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