Maria Petrovna Kruglova 1 , Sergej Vital'evich Grachev 1 , Polina Olegovna Bulgakova 2 , Alexander Vladimirovich Ivanov 2 , Edward Danielevich Virus 2 , Ksenya Alexandrovna Nikiforova 2 , Anatolij Nikolaevich Fedoseev 3 , Galina Dmitrievna Savina 4 , Aslan Amirkhanovich Kubatiev 2 Show Affiliations »
Abstract
OBJECTIVE: To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD). METHODS: Case-control study including 50 patients with CKD and 20 healthy volunteers. RESULTS: SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01). CONCLUSION: CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising. © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
OBJECTIVE: To evaluate the association of S-adenosylmethionine (SAM ) and S-adenosylhomocysteine (SAH ) in urine with chronic kidney disease (CKD ). METHODS: Case-control study including 50 patients with CKD and 20 healthy volunteers. RESULTS: SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01). CONCLUSION: CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising. © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Entities: Chemical
Disease
Gene
Species
Keywords:
S-adenosylhomocysteine; S-adenosylmethionine; chronic kidney disease; homocysteine; hyperhomocysteinemia; urine
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Substances： See more »
Year: 2020
PMID： 31247080 DOI： 10.1093/labmed/lmz035
Source DB: PubMed Journal: Lab Med ISSN： 0007-5027