Ying Huang 1,2 , Hong Jiang 1,2 , Lihua Zhu 1,2 Show Affiliations »
Abstract
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). OBJECTIVE: To assess whether human epididymis protein 4 (HE4) can be useful in diagnosing acute heart failure (AHF) in patients with CKD. METHODS: A cohort of 139 Han nationality female patients with CKD who were hospitalized at Renmin Hospital of Wuhan University, Wuhan, China from January 2015 through November 2017 were included. RESULTS: Multivariable linear regression analysis showed that HE4 levels were significantly associated with N-terminal pro b-type natriuretic peptide (NT-proBNP) after adjustment of kidney function and other confounding factors. In the multivariate logistic regression analysis, HE4 was independently associated with AHF in patients with CKD (odds ratio, 2.120; 95% confidence interval, 1.034-4.344; P = .04). Moreover, according to the optimal cutoff value of 639.6 pmol per L, the area under the curve, sensitivity, and specificity of HE4 were 0.729, 74.2%, and 76.8%, respectively. CONCLUSIONS: During hospitalization, HE4 maybe an useful indicator for diagnosing AHF in patients with CKD. © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). OBJECTIVE: To assess whether human epididymis protein 4 (HE4 ) can be useful in diagnosing acute heart failure (AHF) in patients with CKD. METHODS: A cohort of 139 Han nationality female patients with CKD who were hospitalized at Renmin Hospital of Wuhan University, Wuhan, China from January 2015 through November 2017 were included. RESULTS: Multivariable linear regression analysis showed that HE4 levels were significantly associated with N-terminal pro b-type natriuretic peptide (NT-proBNP) after adjustment of kidney function and other confounding factors. In the multivariate logistic regression analysis, HE4 was independently associated with AHF in patients with CKD (odds ratio, 2.120; 95% confidence interval, 1.034-4.344; P = .04). Moreover, according to the optimal cutoff value of 639.6 pmol per L, the area under the curve, sensitivity, and specificity of HE4 were 0.729, 74.2%, and 76.8%, respectively. CONCLUSIONS: During hospitalization, HE4 maybe an useful indicator for diagnosing AHF in patients with CKD. © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Entities: Disease
Gene
Species
Keywords:
acute heart failure; chronic kidney disease; diagnostic value; human epididymis protein 4; marker; multivariate analysis
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Year: 2020
PMID： 31245814 DOI： 10.1093/labmed/lmz041
Source DB: PubMed Journal: Lab Med ISSN： 0007-5027