Literature DB >> 31244168

Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles.

Huabing Sun1, Liwei Zheng1, Kun Yang1, Marc M Greenberg1.   

Abstract

Electron deficient "holes" migrate over long distances through the π-system in free DNA. Hole transfer efficiency (HTE) is strongly dependent on sequence and π-stacking. However, there is no consensus regarding the effects of nucleosome core particle (NCP) environment on hole migration. We quantitatively determined HTE in free DNA and NCPs by independently generating holes at specific positions in DNA. The relative HTE varied widely with respect to position within the NCP and proximity to tyrosine, which suppresses hole transfer. These data indicate that hole transfer in chromatin will be affected by the DNA sequence and its position with respect to histone proteins within NCPs.

Entities:  

Year:  2019        PMID： 31244168      PMCID： PMC6610759          DOI： 10.1021/jacs.9b03686

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  38 in total

Review 1.  Long-range charge transfer in DNA: transient structural distortions control the distance dependence.

Authors:  G B Schuster
Journal:  Acc Chem Res       Date:  2000-04       Impact factor: 22.384

2.  Proton-coupled electron transfer in duplex DNA: driving force dependence and isotope effects on electrocatalytic oxidation of guanine.

Authors:  S C Weatherly; I V Yang; H H Thorp
Journal:  J Am Chem Soc       Date:  2001-02-14       Impact factor: 15.419

3.  Oxidative charge transport through DNA in nucleosome core particles.

Authors:  Megan E Núñez; Katherine T Noyes; Jacqueline K Barton
Journal:  Chem Biol       Date:  2002-04

4.  Long-distance charge transport in DNA: the hopping mechanism.

Authors:  B Giese
Journal:  Acc Chem Res       Date:  2000-09       Impact factor: 22.384

5.  Effects of strand and directional asymmetry on base-base coupling and charge transfer in double-helical DNA.

Authors:  Melanie A O'Neill; Jacqueline K Barton
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-16       Impact factor: 11.205

6.  The significance of proton migration during hole hopping through DNA.

Authors:  B Giese; S Wessely
Journal:  Chem Commun (Camb)       Date:  2001-10-21       Impact factor: 6.222

7.  Suppression of DNA-mediated charge transport by BamHI binding.

Authors:  Kazuhiko Nakatani; Chikara Dohno; Atsushi Ogawa; Isao Saito
Journal:  Chem Biol       Date:  2002-03

8.  Stable DNA-protein cross-links are products of DNA charge transport in a nucleosome core particle.

Authors:  Chad C Bjorklund; William B Davis
Journal:  Biochemistry       Date:  2007-08-31       Impact factor: 3.162

9.  Dynamics and energetics of single-step hole transport in DNA hairpins.

Authors:  Frederick D Lewis; Jianqin Liu; Xiaobing Zuo; Ryan T Hayes; Michael R Wasielewski
Journal:  J Am Chem Soc       Date:  2003-04-23       Impact factor: 15.419

10.  Attenuation of DNA charge transport by compaction into a nucleosome core particle.

Authors:  Chad C Bjorklund; William B Davis
Journal:  Nucleic Acids Res       Date:  2006-04-04       Impact factor: 16.971
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  6 in total

1.  Independent Generation and Time-Resolved Detection of 2'-Deoxyguanosin-N2-yl Radicals.

Authors:  Liwei Zheng; Xiaojuan Dai; Hongmei Su; Marc M Greenberg
Journal:  Angew Chem Int Ed Engl       Date:  2020-06-02       Impact factor: 15.336

2.  Interplay of Guanine Oxidation and G-Quadruplex Folding in Gene Promoters.

Authors:  Aaron M Fleming; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2020-01-09       Impact factor: 15.419

3.  Reactivity and DNA Damage by Independently Generated 2'-Deoxycytidin-N4-yl Radical.

Authors:  Haihui Peng; Jialong Jie; Ifor P Mortimer; Zehan Ma; Hongmei Su; Marc M Greenberg
Journal:  J Am Chem Soc       Date:  2021-09-01       Impact factor: 16.383

4.  Site of Azido Substitution in the Sugar Moiety of Azidopyrimidine Nucleosides Influences the Reactivity of Aminyl Radicals Formed by Dissociative Electron Attachment.

Authors:  Mukesh Mudgal; Thao P Dang; Adam J Sobczak; Daniel A Lumpuy; Priya Dutta; Samuel Ward; Katherine Ward; Moaadh Alahmadi; Anil Kumar; Michael D Sevilla; Stanislaw F Wnuk; Amitava Adhikary
Journal:  J Phys Chem B       Date:  2020-12-03       Impact factor: 2.991

5.  Participation of Histones in DNA Damage and Repair within Nucleosome Core Particles: Mechanism and Applications.

Authors:  Mengtian Ren; Marc M Greenberg; Chuanzheng Zhou
Journal:  Acc Chem Res       Date:  2022-03-10       Impact factor: 22.384

Review 6.  Ultrafast Processes Occurring in Radiolysis of Highly Concentrated Solutions of Nucleosides/Tides.

Authors:  Jun Ma; Sergey A Denisov; Amitava Adhikary; Mehran Mostafavi
Journal:  Int J Mol Sci       Date:  2019-10-08       Impact factor: 5.923
  6 in total

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