| Literature DB >> 31241075 |
Tianyu Zhu1, Chen Chen1, Sisi Wang1, Yi Zhang1, Dongrong Zhu1, Lingnan Li1, Jianguang Luo1, Lingyi Kong1.
Abstract
Withangulatin A (WA) has been reported to exhibit potent antitumor activity. However, its possible mechanism and direct proteomic targets remain unknown. Herein we report the subcellular localization of WA by designing and synthesizing its fluorescent analogues with coumarin moieties. Furthermore, sarco/endoplasmic reticulum calcium-ATPase (SERCA)2 was identified as the potential target of WA for its antitumor activity by chemical proteomics.Entities:
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Year: 2019 PMID： 31241075 DOI： 10.1039/c9cc03653a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222