Andreas H Kramer1, Karen Hornby2, Christopher J Doig3, Denise Armstrong4, Laura Grantham4, Sherri Kashuba5, Philippe L Couillard6, Demetrios J Kutsogiannis7. 1. Departments of Critical Care Medicine & Clinical Neurosciences, University of Calgary, 3132 Hospital Drive NW, Calgary, AB, Canada. Andreas.Kramer@AlbertaHealthServices.ca. 2. Research Support Services Program, Trillium Gift of Life Network, Toronto, ON, Canada. 3. Departments of Critical Care Medicine & Community Health Sciences, University of Calgary, Calgary, AB, Canada. 4. Alberta Organ & Tissue Donation Program, Calgary, AB, Canada. 5. Critical Care Strategic Clinical Network, Alberta Health Services, Edmonton, AB, Canada. 6. Departments of Critical Care Medicine & Clinical Neurosciences, University of Calgary, 3132 Hospital Drive NW, Calgary, AB, Canada. 7. Department of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada.
Abstract
BACKGROUND: Transplantation is the most effective treatment for many patients with end-stage organ failure. There is a gap between the number of patients who would benefit from transplantation and availability of organs. We assessed maximum potential for deceased donation in Alberta and barriers to increasing the donation rate. METHODS: All deaths that occurred in Alberta in 2015 in areas where mechanical ventilation could be provided were retrospectively identified using administrative data. Medical records were reviewed by donation coordinators and critical care physicians with expertise in donation, using a standardized tool to determine whether deceased patients could potentially have been organ donors. RESULTS: There were 2,706 deaths occurring in either an intensive care unit or emergency department, of which 1,252 were attributable to a non-neurologic cause: 946 involved cardiac arrests with unsuccessful resuscitation, and 57 were not mechanically ventilated. Of the remaining 451 deaths, 117 (28 donors per million population [dpmp]) either were, or could potentially have been, organ donors after neurologic determination of death (NDD). Of these, 19 (4.5 dpmp) were not appropriately identified or referred, and 45 approached families (10.8 dpmp) did not provide consent. Non-identified NDD cases accounted for a larger proportion of deaths due to neurologic causes in emergency departments (18%) than in intensive care units (2%) (P < 0.0001) and in rural (9%) compared with urban centres (3%) (P = 0.05). If routinely available, donation after circulatory death (DCD) could potentially have been possible in as many as 113 (27 dpmp) cases. CONCLUSIONS: Maximum deceased organ donation potential in Alberta is approximately 55 dpmp. The current donation rate has potential to increase with more widespread availability of DCD and a higher consent rate.
BACKGROUND: Transplantation is the most effective treatment for many patients with end-stage organ failure. There is a gap between the number of patients who would benefit from transplantation and availability of organs. We assessed maximum potential for deceased donation in Alberta and barriers to increasing the donation rate. METHODS: All deaths that occurred in Alberta in 2015 in areas where mechanical ventilation could be provided were retrospectively identified using administrative data. Medical records were reviewed by donation coordinators and critical care physicians with expertise in donation, using a standardized tool to determine whether deceased patients could potentially have been organ donors. RESULTS: There were 2,706 deaths occurring in either an intensive care unit or emergency department, of which 1,252 were attributable to a non-neurologic cause: 946 involved cardiac arrests with unsuccessful resuscitation, and 57 were not mechanically ventilated. Of the remaining 451 deaths, 117 (28 donors per million population [dpmp]) either were, or could potentially have been, organ donors after neurologic determination of death (NDD). Of these, 19 (4.5 dpmp) were not appropriately identified or referred, and 45 approached families (10.8 dpmp) did not provide consent. Non-identified NDD cases accounted for a larger proportion of deaths due to neurologic causes in emergency departments (18%) than in intensive care units (2%) (P < 0.0001) and in rural (9%) compared with urban centres (3%) (P = 0.05). If routinely available, donation after circulatory death (DCD) could potentially have been possible in as many as 113 (27 dpmp) cases. CONCLUSIONS: Maximum deceased organ donation potential in Alberta is approximately 55 dpmp. The current donation rate has potential to increase with more widespread availability of DCD and a higher consent rate.
Authors: Andreas H Kramer; Kerry Holliday; Sean Keenan; George Isac; Demetrios J Kutsogiannis; Norman M Kneteman; Adrian Robertson; Peter Nickerson; Lee Anne Tibbles Journal: Can J Anaesth Date: 2020-02-25 Impact factor: 5.063
Authors: Nathan B Scales; Christophe L Herry; Amanda van Beinum; Melanie L Hogue; Laura Hornby; Jason Shahin; Sonny Dhanani; Andrew J E Seely Journal: Crit Care Explor Date: 2022-04-07