Serine Sahakyan1, Varduhi Petrosyan2, Lusine Abrahamyan2,3,4. 1. Gerald and Patricia Turpanjian School of Public Health, American University of Armenia, Room 410W, Baghramyan 40, 0019, Yerevan, Armenia. s.sahakyan@aua.am. 2. Gerald and Patricia Turpanjian School of Public Health, American University of Armenia, Room 410W, Baghramyan 40, 0019, Yerevan, Armenia. 3. Toronto Health Economics and Technology Assessment (THETA) Collaborative, University of Toronto, Toronto, ON, Canada. 4. Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, ON, Canada.
Abstract
OBJECTIVES: This study aimed to investigate the impact of diabetes on the treatment outcomes among pulmonary TB patients in Yerevan, Armenia. METHODS: We utilized a cohort study design that included TB patients with diabetes and TB patients without diabetes. The data collection was conducted in the National Tuberculosis Control Center, eight tuberculosis outpatient centers and the 'Prisoners' Hospital' in Yerevan, Armenia. Data were collected from an existing national TB database and patients medical records. Multivariable logistic regressions were conducted to construct the final model and test the associations. RESULTS: The final sample included 621 patients 5.8% of whom had diabetes. The odds of having treatment failure was 8.99 times higher among TB patients with diabetes (95% confidence interval 2.51-32.23) compared to TB patients without diabetes after adjusting for weight and sputum smear status. CONCLUSIONS: Diabetes comorbidity had a negative effect on TB treatment outcomes. Countries with a high burden of both TB and diabetes need to develop mechanisms for active screening for diabetes among patients with TB and address their treatment needs carefully.
OBJECTIVES: This study aimed to investigate the impact of diabetes on the treatment outcomes among pulmonary TBpatients in Yerevan, Armenia. METHODS: We utilized a cohort study design that included TBpatients with diabetes and TBpatients without diabetes. The data collection was conducted in the National Tuberculosis Control Center, eight tuberculosisoutpatient centers and the 'Prisoners' Hospital' in Yerevan, Armenia. Data were collected from an existing national TB database and patients medical records. Multivariable logistic regressions were conducted to construct the final model and test the associations. RESULTS: The final sample included 621 patients 5.8% of whom had diabetes. The odds of having treatment failure was 8.99 times higher among TBpatients with diabetes (95% confidence interval 2.51-32.23) compared to TBpatients without diabetes after adjusting for weight and sputum smear status. CONCLUSIONS:Diabetes comorbidity had a negative effect on TB treatment outcomes. Countries with a high burden of both TB and diabetes need to develop mechanisms for active screening for diabetes among patients with TB and address their treatment needs carefully.
Authors: Hanneke M J Nijland; Rovina Ruslami; Janneke E Stalenhoef; Erni J Nelwan; Bachti Alisjahbana; Ron H H Nelwan; Andre J A M van der Ven; Halim Danusantoso; Rob E Aarnoutse; Reinout van Crevel Journal: Clin Infect Dis Date: 2006-08-22 Impact factor: 9.079
Authors: T Santha; R Garg; T R Frieden; V Chandrasekaran; R Subramani; P G Gopi; N Selvakumar; S Ganapathy; N Charles; J Rajamma; P R Narayanan Journal: Int J Tuberc Lung Dis Date: 2002-09 Impact factor: 2.373
Authors: Jette B Kornum; Reimar W Thomsen; Anders Riis; Hans-Henrik Lervang; Henrik C Schønheyder; Henrik T Sørensen Journal: Diabetes Care Date: 2007-06-26 Impact factor: 19.112
Authors: M Martins; J M Boavida; J F Raposo; F Froes; B Nunes; R T Ribeiro; M P Macedo; C Penha-Gonçalves Journal: BMJ Open Diabetes Res Care Date: 2016-05-20
Authors: Sherali Massavirov; Kristina Akopyan; Fazlkhan Abdugapparov; Ana Ciobanu; Arax Hovhanessyan; Mavluda Khodjaeva; Jamshid Gadoev; Nargiza Parpieva Journal: Int J Environ Res Public Health Date: 2021-04-27 Impact factor: 3.390