| Literature DB >> 31240305 |
Jun-Ichi Kawada1, Yasuko Kamiya1, Akihisa Sawada2, Keiji Iwatsuki3, Koji Izutsu4, Yuka Torii1, Hiroshi Kimura5, Yoshinori Ito1.
Abstract
To evaluate diagnostic values for Epstein-Barr virus (EBV) DNA loads in different blood components of patients with EBV-positive T-cell/natural killer cell lymphoproliferative diseases, EBV DNA loads were compared among disease categories in each blood component from 59 patients. Plasma viral loads were significantly higher in "active" disease in chronic active EBV infection. EBV DNA was not detected in the plasma from 7 patients in whom EBV DNA was detected in peripheral blood mononuclear cells and whole blood. Diagnostic cutoff values for whole blood EBV DNA loads of patients with chronic active EBV infection compared with those of infectious mononucleosis was 104.2 (15 800) IU/mL.Entities:
Keywords: EBV-positive T/NK cell lymphoproliferative diseases; chronic active EBV infection; cutoff value; infectious mononucleosis; real-time PCR
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Year: 2019 PMID： 31240305 DOI： 10.1093/infdis/jiz315
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226