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Literature DB >> 3124024

Spontaneous synaptic potentials in dopamine-denervated neostriatal neurons.

E Galarraga¹, J Bargas, D Martínez-Fong, J Aceves.

Abstract

Intracellular spontaneous activity was recorded in neostriatal slices from rats with 6-hydroxydopamine-induced lesion of the left nigrostriatal dopaminergic system. Recordings were made at different times after denervation. Dopaminergic denervation caused the appearance of spontaneous synaptic potentials, which were present even after 8 months. The results suggest a tonic inhibitory influence of the dopaminergic innervation on the synaptic input of neostriatal neurons.

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Year: 1987 PMID： 3124024 DOI： 10.1016/0304-3940(87)90409-5

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

14 in total

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Spontaneous synaptic potentials in dopamine-denervated neostriatal neurons.

1. Differential structural plasticity of corticostriatal and thalamostriatal axo-spinous synapses in MPTP-treated Parkinsonian monkeys.

2. Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway.

Review 3. Deep brain stimulation: are astrocytes a key driver behind the scene?

4. Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats.

5. Cortical slow oscillatory activity is reflected in the membrane potential and spike trains of striatal neurons in rats with chronic nigrostriatal lesions.

6. Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: ultrastructural localization and electrophysiological effects of activation in the striatopallidal complex.

7. Effect of 5-hydroxytryptamine on [3H]-acetylcholine release from guinea-pig striatal slices.

8. Inversion of dopamine responses in striatal medium spiny neurons and involuntary movements.

9. Dopamine-dependent synaptic plasticity in striatum during in vivo development.

10. Neuroglial plasticity at striatal glutamatergic synapses in Parkinson's disease.