Literature DB >> 31238113

Drug repurposing: a promising tool to accelerate the drug discovery process.

Vineela Parvathaneni1, Nishant S Kulkarni1, Aaron Muth1, Vivek Gupta2.   

Abstract

Traditional drug discovery and development involves several stages for the discovery of a new drug and to obtain marketing approval. It is necessary to discover new strategies for reducing the drug discovery time frame. Today, drug repurposing has gained importance in identifying new therapeutic uses for already-available drugs. Typically, repurposing can be achieved serendipitously (unintentional fortunate observations) or through systematic approaches. Numerous strategies to discover new indications for FDA-approved drugs are discussed in this article. Drug repurposing has therefore become a productive approach for drug discovery because it provides a novel way to explore old drugs for new use but encounters several challenges. Some examples of different approaches are reviewed here.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Mesh:

Year:  2019        PMID: 31238113     DOI: 10.1016/j.drudis.2019.06.014

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  47 in total

Review 1.  Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders.

Authors:  Dharmendra Kumar Khatri; Amey Kadbhane; Monica Patel; Shweta Nene; Srividya Atmakuri; Saurabh Srivastava; Shashi Bala Singh
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-04-08

2.  Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival.

Authors:  Florent Busi; Florian Turbant; Jehan Waeytens; Omar El Hamoui; Frank Wien; Véronique Arluison
Journal:  Methods Mol Biol       Date:  2022

3.  Exploring Amodiaquine's Repurposing Potential in Breast Cancer Treatment-Assessment of In-Vitro Efficacy & Mechanism of Action.

Authors:  Vineela Parvathaneni; Rameswari Chilamakuri; Nishant S Kulkarni; Nabeela F Baig; Saurabh Agarwal; Vivek Gupta
Journal:  Int J Mol Sci       Date:  2022-09-28       Impact factor: 6.208

Review 4.  Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer.

Authors:  Ye Li; Zhuo-Kun Chen; Xu Duan; He-Jing Zhang; Bo-Lin Xiao; Kui-Ming Wang; Gang Chen
Journal:  Exp Mol Med       Date:  2022-09-18       Impact factor: 12.153

Review 5.  Drug repurposing-an emerging strategy in cancer therapeutics.

Authors:  Khadija Shahab Turabi; Ankita Deshmukh; Sayan Paul; Dayanand Swami; Shafina Siddiqui; Urwashi Kumar; Shreelekha Naikar; Shine Devarajan; Soumya Basu; Manash K Paul; Jyotirmoi Aich
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-06-13       Impact factor: 3.195

6.  Reconciling multiple connectivity scores for drug repurposing.

Authors:  Kewalin Samart; Phoebe Tuyishime; Arjun Krishnan; Janani Ravi
Journal:  Brief Bioinform       Date:  2021-11-05       Impact factor: 11.622

7.  Repurposing Bedaquiline for Effective Non-Small Cell Lung Cancer (NSCLC) Therapy as Inhalable Cyclodextrin-Based Molecular Inclusion Complexes.

Authors:  Vineela Parvathaneni; Rasha S Elbatanony; Mimansa Goyal; Tejashri Chavan; Nathan Vega; Srikanth Kolluru; Aaron Muth; Vivek Gupta; Nitesh K Kunda
Journal:  Int J Mol Sci       Date:  2021-04-30       Impact factor: 5.923

8.  Identification and Development of Therapeutics for COVID-19.

Authors:  Halie M Rando; Nils Wellhausen; Soumita Ghosh; Alexandra J Lee; Anna Ada Dattoli; Fengling Hu; James Brian Byrd; Diane N Rafizadeh; Ronan Lordan; Yanjun Qi; Yuchen Sun; Christian Brueffer; Jeffrey M Field; Marouen Ben Guebila; Nafisa M Jadavji; Ashwin N Skelly; Bharath Ramsundar; Jinhui Wang; Rishi Raj Goel; YoSon Park; Simina M Boca; Anthony Gitter; Casey S Greene
Journal:  mSystems       Date:  2021-11-02       Impact factor: 6.496

9.  Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome.

Authors:  David J Lowes; Kirk E Hevener; Brian M Peters
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

Review 10.  Statin as a Potential Chemotherapeutic Agent: Current Updates as a Monotherapy, Combination Therapy, and Treatment for Anti-Cancer Drug Resistance.

Authors:  Nirmala Tilija Pun; Chul-Ho Jeong
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-16
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