Patients with chronic hepatitis B (CHB) are aging because of improved survival under better health care. This has an important implication on the choice of antiviral treatment (AVT), given that long-term safety would be a concern in the presence of multiple comorbidities. We aimed to determine the prevalence of key comorbidities and concomitant medications in a territory-wide CHB cohort in Hong Kong in 2000-2017. CHB patients who have been under the care at primary, secondary, and tertiary medical centers in the public sector were identified through the Clinical Data Analysis and Reporting System of the Hospital Authority, Hong Kong. The demographics and prevalence of key comorbidities, including diabetes mellitus, hypertension, chronic kidney disease, osteopenia/osteoporosis based on diagnosis codes, relevant medications, and/or laboratory parameters, were determined according to CHB patients' first appearance in four time periods: 2000-2004, 2005-2009, 2010-2013, and 2014-2017. In the final analysis, 135,395 CHB patients were included; the mean age increased with time: 41 ± 15 years in 2000-2004; 46 ± 17 years in 2005-2009; 51 ± 16 years in 2010-2013; and 55 ± 15 years in 2014-2017. There was a trend of increasing prevalence of several common comorbidities over the four periods: hypertension 25.5%, 23.8%, 27.2%, and 28.6%; diabetes mellitus 10.6%, 12.5%, 16.1%, and 20.1%; cardiovascular disease 12.5%, 16.9%, 20.9%, and 22.2%; and malignancy 7.0%, 13.2%, 17.3%, and 23.6%, respectively (all P < 0.001). Conclusion: CHB patients are getting older with increasing prevalence of common comorbidities. These comorbidities should be taken into account when choosing AVT.
Patients with chronic hepatitis B (CHB) are aging because of improved survival under better health care. This has an important implication on the choice of antiviral treatment (AVT), given that long-term safety would be a concern in the presence of multiple comorbidities. We aimed to determine the prevalence of key comorbidities and concomitant medications in a territory-wide CHB cohort in Hong Kong in 2000-2017. CHB patients who have been under the care at primary, secondary, and tertiary medical centers in the public sector were identified through the Clinical Data Analysis and Reporting System of the Hospital Authority, Hong Kong. The demographics and prevalence of key comorbidities, including diabetes mellitus, hypertension, chronic kidney disease, osteopenia/osteoporosis based on diagnosis codes, relevant medications, and/or laboratory parameters, were determined according to CHB patients' first appearance in four time periods: 2000-2004, 2005-2009, 2010-2013, and 2014-2017. In the final analysis, 135,395 CHB patients were included; the mean age increased with time: 41 ± 15 years in 2000-2004; 46 ± 17 years in 2005-2009; 51 ± 16 years in 2010-2013; and 55 ± 15 years in 2014-2017. There was a trend of increasing prevalence of several common comorbidities over the four periods: hypertension 25.5%, 23.8%, 27.2%, and 28.6%; diabetes mellitus 10.6%, 12.5%, 16.1%, and 20.1%; cardiovascular disease 12.5%, 16.9%, 20.9%, and 22.2%; and malignancy 7.0%, 13.2%, 17.3%, and 23.6%, respectively (all P < 0.001). Conclusion: CHB patients are getting older with increasing prevalence of common comorbidities. These comorbidities should be taken into account when choosing AVT.
Authors: Terry Cheuk-Fung Yip; Raymond Ngai Chiu Chan; Vincent Wai-Sun Wong; Yee-Kit Tse; Lilian Yan Liang; Vicki Wing-Ki Hui; Xinrong Zhang; Guan-Lin Li; Henry Lik-Yuen Chan; Grace Lai-Hung Wong Journal: Health Sci Rep Date: 2021-08-11
Authors: Rosyli F Reveron-Thornton; Margaret L P Teng; Eunice Yewon Lee; Andrew Tran; Sean Vajanaphanich; Eunice X Tan; Sanjna N Nerurkar; Rui Xin Ng; Readon Teh; Debi Prasad Tripathy; Takanori Ito; Taku Tanaka; Nozomi Miyake; Biyao Zou; Connie Wong; Hidenori Toyoda; Carlos O Esquivel; C Andrew Bonham; Mindie H Nguyen; Daniel Q Huang Journal: Hepatol Commun Date: 2022-03-02
Authors: Stephen Lam Chan; Terry Cheuk-Fung Yip; Vincent Wai-Sun Wong; Yee-Kit Tse; Becky Wing-Yan Yuen; Hester Wing-Sum Luk; Rashid Nok-Shun Lui; Henry Lik-Yuen Chan; Tony Shu-Kam Mok; Grace Lai-Hung Wong Journal: Cancer Med Date: 2020-08-11 Impact factor: 4.452