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Literature DB >> 3123711

Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant.

M N Pensiero¹, G B Jennings, C S Schmaljohn, J Hay.

Abstract

A cDNA containing the complete open reading frame of the Hantaan virus (HTN) M genome segment has been cloned into vaccinia virus. This recombinant virus expresses two glycoproteins which are similar to the HTN structural glycoproteins, G1 and G2, in molecular weight, cleavage pattern, and cellular distribution. Both HTN and recombinant vaccinia virus glycoproteins are exclusively associated with the Golgi apparatus of the cell. Despite this intracellular restriction, mice inoculated with the recombinant vaccinia virus raised neutralizing antibodies against HTN. The specificity of virus neutralization appears to reside in the HTN glycoproteins, since a vaccinia virus recombinant expressing the HTN nucleocapsid protein was unable to elicit a neutralizing antibody response.

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Year: 1988 PMID： 3123711 PMCID： PMC253622

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

Review 1. Korean hemorrhagic fever.

Authors: H W Lee
Journal: Prog Med Virol Date: 1982

2. Differential immunologic reactivity and processing of glycoproteins gA and gB of herpes simplex virus types 1 and 2 made in Vero and HEp-2 cells.

Authors: L Pereira; D Dondero; B Norrild; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 1981-08 Impact factor: 11.205

3. Hantaan virus: identification of virion proteins.

Authors: L H Elliott; M P Kiley; J B McCormick
Journal: J Gen Virol Date: 1984-08 Impact factor: 3.891

4. Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order.

Authors: C S Schmaljohn; A L Schmaljohn; J M Dalrymple
Journal: Virology Date: 1987-03 Impact factor: 3.616

5. Characterization of Hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome.

Authors: C S Schmaljohn; S E Hasty; S A Harrison; J M Dalrymple
Journal: J Infect Dis Date: 1983-12 Impact factor: 5.226

6. Analysis of Hantaan virus RNA: evidence for a new genus of bunyaviridae.

Authors: C S Schmaljohn; J M Dalrymple
Journal: Virology Date: 1983-12 Impact factor: 3.616

7. The complete sequence of the M RNA of snowshoe hare bunyavirus reveals the presence of internal hydrophobic domains in the viral glycoprotein.

Authors: Y Eshita; D H Bishop
Journal: Virology Date: 1984-09 Impact factor: 3.616

8. Live recombinant vaccinia virus protects chimpanzees against hepatitis B.

Authors: B Moss; G L Smith; J L Gerin; R H Purcell
Journal: Nature Date: 1984 Sep 6-11 Impact factor: 49.962

9. Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

Authors: S Chakrabarti; K Brechling; B Moss
Journal: Mol Cell Biol Date: 1985-12 Impact factor: 4.272

10. Hepatitis B virus large surface protein is not secreted but is immunogenic when selectively expressed by recombinant vaccinia virus.

Authors: K C Cheng; G L Smith; B Moss
Journal: J Virol Date: 1986-11 Impact factor: 5.103

29 in total

1. Molecular cloning and high-level expression of G2 protein of hantaan (HTN) virus 76-118 strain in the yeast Pichia pastoris KM71.

Authors: S H Ha; J J Park; J W Kim; J W Jeong; K S Noh; Y J Jeon; H S Kim; H B Kim
Journal: Virus Genes Date: 2001-03 Impact factor: 2.332

2. Nucleotide sequence of the L genome segment of Hantaan virus.

Authors: C S Schmaljohn
Journal: Nucleic Acids Res Date: 1990-11-25 Impact factor: 16.971

3. Role of vascular and lymphatic endothelial cells in hantavirus pulmonary syndrome suggests targeted therapeutic approaches.

Authors: Erich R Mackow; Elena E Gorbunova; Nadine A Dalrymple; Irina N Gavrilovskaya
Journal: Lymphat Res Biol Date: 2013-09-11 Impact factor: 2.589

Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant.

Review 1. Korean hemorrhagic fever.

2. Differential immunologic reactivity and processing of glycoproteins gA and gB of herpes simplex virus types 1 and 2 made in Vero and HEp-2 cells.

3. Hantaan virus: identification of virion proteins.

4. Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order.

5. Characterization of Hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome.

6. Analysis of Hantaan virus RNA: evidence for a new genus of bunyaviridae.

7. The complete sequence of the M RNA of snowshoe hare bunyavirus reveals the presence of internal hydrophobic domains in the viral glycoprotein.

8. Live recombinant vaccinia virus protects chimpanzees against hepatitis B.

9. Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

10. Hepatitis B virus large surface protein is not secreted but is immunogenic when selectively expressed by recombinant vaccinia virus.

1. Molecular cloning and high-level expression of G2 protein of hantaan (HTN) virus 76-118 strain in the yeast Pichia pastoris KM71.

2. Nucleotide sequence of the L genome segment of Hantaan virus.

3. Role of vascular and lymphatic endothelial cells in hantavirus pulmonary syndrome suggests targeted therapeutic approaches.

4. The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses.

5. Localization to the Golgi complex of Uukuniemi virus glycoproteins G1 and G2 expressed from cloned cDNAs.

6. Oligomerization, transport, and Golgi retention of Punta Toro virus glycoproteins.

7. Tyrosine residues direct the ubiquitination and degradation of the NY-1 hantavirus G1 cytoplasmic tail.

8. Assembly and polarized release of Punta Toro virus and effects of brefeldin A.

9. The Hantaan virus M-segment glycoproteins G1 and G2 can be expressed independently.

10. Hantaan virus infection of human endothelial cells.