Literature DB >> 31236761

Role of Wnt3a in the pathogenesis of cancer, current status and prospective.

Mehran Pashirzad1, Hamid Fiuji2, Majid Khazei3, Maryam Moradi-Binabaj1, Mikhail Ryzhikov4, Mohammad Shabani5, Amir Avan6, Seyed Mahdi Hassanian7,8,9.   

Abstract

The Wnt signaling pathway plays a critical role in initiation, progression, invasion and metastasis of cancer. Wnt3a as a canonical Wnt ligand is strongly implicated in the etiology and pathology of a number of diseases including cancer. Depending on cancer type, Wnt3a enhances or suppresses metastasis, cell proliferation and apoptosis of cancer cells. This review summarizes the role of Wnt3a in the pathogenesis of different cancers including colorectal, prostate, hepatocellular, lung and leukemia, for promoting greater understanding and clinical management of these diseases.

Entities:  

Keywords:  Cancer; Wnt signaling; Wnt3a

Mesh：

Substances：

Year:  2019        PMID： 31236761     DOI： 10.1007/s11033-019-04895-4

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  4 in total

1.  Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45.

Authors:  Masaru Katoh
Journal:  Int J Oncol       Date:  2002-02       Impact factor: 5.650

2.  Redundant expression of canonical Wnt ligands in human breast cancer cell lines.

Authors:  Khemais Benhaj; Kamil Can Akcali; Mehmet Ozturk
Journal:  Oncol Rep       Date:  2006-03       Impact factor: 3.906

3.  Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a.

Authors:  Siwei Wang; Mantang Qiu; Wenjia Xia; Youtao Xu; Qixing Mao; Jie Wang; Gaochao Dong; Lin Xu; Xin Yang; Rong Yin
Journal:  Oncotarget       Date:  2016-11-29

4.  The chromatin-remodeling enzyme BRG1 promotes colon cancer progression via positive regulation of WNT3A.

Authors:  Shengtao Lin; Tao Jiang; Ling Ye; Zhongbo Han; Yuan Liu; Chenchen Liu; Chenwei Yuan; Senlin Zhao; Jian Chen; Jingtao Wang; Huamei Tang; Su Lu; Liguang Yang; Xiaoliang Wang; Dongwang Yan; Zhihai Peng; Junwei Fan
Journal:  Oncotarget       Date:  2016-12-27
  4 in total
  4 in total

Review 1.  Wnt/β-catenin signaling in cancers and targeted therapies.

Authors:  Fanyuan Yu; Changhao Yu; Feifei Li; Yanqin Zuo; Yitian Wang; Lin Yao; Chenzhou Wu; Chenglin Wang; Ling Ye
Journal:  Signal Transduct Target Ther       Date:  2021-08-30

2.  Long Non-Coding RNA Cancer Susceptibility Candidate 9 Regulates the Malignant Biological Behavior of Nasopharyngeal Carcinoma Cells by Targeting miR-497-5p/Wnt3a/β-catenin Signaling Pathway.

Authors:  Yue Lei; Wenlong Luo; Qiuyue Gong; Lan Luo; Wuyang Jing
Journal:  Front Oncol       Date:  2022-03-28       Impact factor: 6.244

3.  Integrated Analysis of DNA Repair Genes Identifies SLC6A1 as a New Marker for the Clinical Outcome of Patients with Colorectal Cancer.

Authors:  Qian-Qian Wang; Yang Wei; Li-Ping Luo; Xin Li; Wen-Jun Jiang
Journal:  Dis Markers       Date:  2022-02-22       Impact factor: 3.434

4.  Transcriptome Analysis Reveals the Neuro-Immune Interactions in Duck Tembusu Virus-Infected Brain.

Authors:  Junqin Zhang; Yunzhen Huang; Linlin Li; Jiawen Dong; Ming Liao; Minhua Sun
Journal:  Int J Mol Sci       Date:  2020-03-31       Impact factor: 5.923
  4 in total

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